Prognostic implications of cytopathologic classification of melanocytic uveal tumors evaluated by fine-needle aspiration biopsy

James Jay Augsburger, Zélia Maria Corrêa, Nikolaos Trichopoulos

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Purpose: Determine whether cytopathologic classification of melanocytic uveal tumors evaluated by fine-needle aspiration biopsy (FNAB) is a significant prognostic factor for death from metastasis. Methods: Retrospective analysis of cases of clinically diagnosed uveal melanoma evaluated by fine-needle aspiration biopsy from 1980 to 2006. Main outcome evaluated was death from metastasis. Associations between baseline clinical variables and cytopathologic classification were evaluated using cross-tabulation. Prognostic significance of cytopathologic classification was evaluated by Kaplan- Meier and Cox proportional hazards analysis. Results: Of 302 studied biopsies, 260 (86.1%) yielded sufficient cells for cytopathologic classification. Eighty of the 260 patients who had a sufficient specimen have already died (P=0.021), 69 from metastatic uveal melanoma. Cell type assigned by cytopathology was strongly associated with metastasis/metastatic death in this series (P=0.0048). Multivariate analysis showed cytopathologic classification to be an independently significant prognostic factor for metastatic death (P=0.0006). None of the 42 patients whose tumor yielded insufficient aspirates (sampled in at least two sites) have developed metastasis or died of metastasis thus far. Conclusion: In this series, cytopathology of fine-needle aspiration biopsy samples obtained from uveal melanomas was strongly prognostic of death from metastasis. Insufficiently aspirates (2 or more sites sampled) proved to be prognostic of a favorable outcome (i.e., not developing metastasis).

Original languageEnglish (US)
Pages (from-to)72-79
Number of pages8
JournalArquivos Brasileiros de Oftalmologia
Volume76
Issue number2
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Biopsy needle/methods
  • Biopsy, fine-needle
  • Choroid neoplasms
  • Cytodiagnosis
  • Melanoma/ surgery
  • Melanoma/diagnosis
  • Uveal neoplasms/pathology

ASJC Scopus subject areas

  • Ophthalmology

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