Prognostic features and markers for testicular cancer management

Eddy S. Leman, Mark L. Gonzalgo

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Testicular neoplasm accounts for about 1% of all cancers in men. Over the last 40 years, the incidence of testicular cancer has increased in northern European male populations for unknown reasons. When diagnosed at early stage, testicular cancer is usually curable with a high survival rate. In the past three decades, successful multidisciplinary approaches for the management of testicular cancer have significantly increased patient survival rates. Utilization of tumor markers and accurate prognostic classification has also contributed to successful therapy. In this article, we highlight the most commonly used tumor markers and several potential "novel" markers for testicular cancer as part of the ongoing effort in biomarker research and discovery. In addition, this article also identifies several key prognostic features that have been demonstrated to play a role in predicting relapse. These features include tumor size, rete testis invasion, lymphovascular invasion, and tumor histology. Together with tumor markers, these prognostic factors should be taken into account for risk-adapted management of testicular cancer.

Original languageEnglish (US)
Pages (from-to)76-81
Number of pages6
JournalIndian Journal of Urology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Non-seminoma
  • Prognostic factors
  • Seminoma
  • Testicular cancer
  • Tumor markers

ASJC Scopus subject areas

  • Urology

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