Prognostic factors in patients with advanced cholangiocarcinoma: Role of surgery, chemotherapy and body mass index

Mirna H. Farhat, Ali I. Shamseddine, Ayman N. Tawil, Ghina Berjawi, Charif Sidani, Wael Shamseddeen, Kassem A. Barada

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Aim: To study the factors that may affect survival of cholangiocarcinoma in Lebanon. Methods: A retrospective review of the medical records of 55 patients diagnosed with cholangiocarcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival. Results: The median survival of all patients was 8.57 mo (0.03-105.2). Univariate analysis showed that low bilirubin level (< 10 mg/dL), radical surgery and chemotherapy administration were significantly associated with better survival (P = 0.012, 0.038 and 0.038, respectively). In subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly (17.0 mo vs 3.5 mo, P = 0.001). Multivariate analysis identified only low bilirubin level < 10 mg/dL and chemotherapy administration as independent predictors associated with better survival (P < 0.05). Conclusion: Our data show that palliative and postoperative chemotherapy as well as a bilirubin level < 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma.

Original languageEnglish
Pages (from-to)3224-3230
Number of pages7
JournalWorld Journal of Gastroenterology
Volume14
Issue number20
DOIs
StatePublished - May 28 2008
Externally publishedYes

Fingerprint

Cholangiocarcinoma
Body Mass Index
Drug Therapy
Survival
Bilirubin
Multivariate Analysis
Lebanon
Medical Records

Keywords

  • Biliary tract cancer
  • Bilirubin
  • Chemotherapy
  • Cholangiocarcinoma
  • Prognosis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prognostic factors in patients with advanced cholangiocarcinoma : Role of surgery, chemotherapy and body mass index. / Farhat, Mirna H.; Shamseddine, Ali I.; Tawil, Ayman N.; Berjawi, Ghina; Sidani, Charif; Shamseddeen, Wael; Barada, Kassem A.

In: World Journal of Gastroenterology, Vol. 14, No. 20, 28.05.2008, p. 3224-3230.

Research output: Contribution to journalArticle

Farhat, Mirna H. ; Shamseddine, Ali I. ; Tawil, Ayman N. ; Berjawi, Ghina ; Sidani, Charif ; Shamseddeen, Wael ; Barada, Kassem A. / Prognostic factors in patients with advanced cholangiocarcinoma : Role of surgery, chemotherapy and body mass index. In: World Journal of Gastroenterology. 2008 ; Vol. 14, No. 20. pp. 3224-3230.
@article{ac11b6ac9e05465182d4377b86b1faf1,
title = "Prognostic factors in patients with advanced cholangiocarcinoma: Role of surgery, chemotherapy and body mass index",
abstract = "Aim: To study the factors that may affect survival of cholangiocarcinoma in Lebanon. Methods: A retrospective review of the medical records of 55 patients diagnosed with cholangiocarcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival. Results: The median survival of all patients was 8.57 mo (0.03-105.2). Univariate analysis showed that low bilirubin level (< 10 mg/dL), radical surgery and chemotherapy administration were significantly associated with better survival (P = 0.012, 0.038 and 0.038, respectively). In subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly (17.0 mo vs 3.5 mo, P = 0.001). Multivariate analysis identified only low bilirubin level < 10 mg/dL and chemotherapy administration as independent predictors associated with better survival (P < 0.05). Conclusion: Our data show that palliative and postoperative chemotherapy as well as a bilirubin level < 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma.",
keywords = "Biliary tract cancer, Bilirubin, Chemotherapy, Cholangiocarcinoma, Prognosis",
author = "Farhat, {Mirna H.} and Shamseddine, {Ali I.} and Tawil, {Ayman N.} and Ghina Berjawi and Charif Sidani and Wael Shamseddeen and Barada, {Kassem A.}",
year = "2008",
month = "5",
day = "28",
doi = "10.3748/wjg.14.3224",
language = "English",
volume = "14",
pages = "3224--3230",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "20",

}

TY - JOUR

T1 - Prognostic factors in patients with advanced cholangiocarcinoma

T2 - Role of surgery, chemotherapy and body mass index

AU - Farhat, Mirna H.

AU - Shamseddine, Ali I.

AU - Tawil, Ayman N.

AU - Berjawi, Ghina

AU - Sidani, Charif

AU - Shamseddeen, Wael

AU - Barada, Kassem A.

PY - 2008/5/28

Y1 - 2008/5/28

N2 - Aim: To study the factors that may affect survival of cholangiocarcinoma in Lebanon. Methods: A retrospective review of the medical records of 55 patients diagnosed with cholangiocarcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival. Results: The median survival of all patients was 8.57 mo (0.03-105.2). Univariate analysis showed that low bilirubin level (< 10 mg/dL), radical surgery and chemotherapy administration were significantly associated with better survival (P = 0.012, 0.038 and 0.038, respectively). In subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly (17.0 mo vs 3.5 mo, P = 0.001). Multivariate analysis identified only low bilirubin level < 10 mg/dL and chemotherapy administration as independent predictors associated with better survival (P < 0.05). Conclusion: Our data show that palliative and postoperative chemotherapy as well as a bilirubin level < 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma.

AB - Aim: To study the factors that may affect survival of cholangiocarcinoma in Lebanon. Methods: A retrospective review of the medical records of 55 patients diagnosed with cholangiocarcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival. Results: The median survival of all patients was 8.57 mo (0.03-105.2). Univariate analysis showed that low bilirubin level (< 10 mg/dL), radical surgery and chemotherapy administration were significantly associated with better survival (P = 0.012, 0.038 and 0.038, respectively). In subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly (17.0 mo vs 3.5 mo, P = 0.001). Multivariate analysis identified only low bilirubin level < 10 mg/dL and chemotherapy administration as independent predictors associated with better survival (P < 0.05). Conclusion: Our data show that palliative and postoperative chemotherapy as well as a bilirubin level < 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma.

KW - Biliary tract cancer

KW - Bilirubin

KW - Chemotherapy

KW - Cholangiocarcinoma

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=48949093689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48949093689&partnerID=8YFLogxK

U2 - 10.3748/wjg.14.3224

DO - 10.3748/wjg.14.3224

M3 - Article

C2 - 18506930

AN - SCOPUS:48949093689

VL - 14

SP - 3224

EP - 3230

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 20

ER -