Prognosis of Patients with Bilateral Macular Drusen

William E. Smiddy, Stuart L. Fine

Research output: Contribution to journalArticlepeer-review

170 Scopus citations


Of 71 patients with only bilateral macular drusen, 8 eyes in 7 patients (9.9%) developed exudative maculopathy over an average follow-up of 4.3 years (14.5% cumulative risk). Severe visual loss due to exudative maculopathy occurred in 7 eyes of 6 patients (8.5% for a 5-year cumulative risk of 12.7%. Features of the drusen were analyzed, but only the association with focal hyperpigmentation (P < 0.001) and more than minimal drusen confluence (P < 0.05) were statistically significant. Older patients had more severe drusen. Photostress test delay did not correlate with visual acuity, age, or severity of drusen.

Original languageEnglish (US)
Pages (from-to)271-277
Number of pages7
Issue number3
StatePublished - Jan 1 1984
Externally publishedYes


  • choroidal neovascularization
  • drusen
  • photostress test
  • risk factors
  • senile macular degeneration

ASJC Scopus subject areas

  • Ophthalmology


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