Proglycogen

A low-molecular-weight form of muscle glycogen

Joseph Lomako, Wieslawa M. Lomako, William J. Whelan

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

We recently reported that muscle contains a trichloroacetic acid-precipitable component having Mr approx. 400 kDa that can be glucosylated by an endogenous enzyme acting on UDPglucose. This component contains within itself the autocatalytic, self glucosylating protein glycogenin, the primer for glycogen synthesis. We now report that this substance, to which we give the name proglycogen, is a glycogen-like molecule constituting about 15% or total glycogen. It acts as a very efficient acceptor of glucose residues added from UDPglucose. Further, that the endogenous enzyme that adds the glucose to proglycogen is not the autocatalytic protein but a glycogen synthase-like enzyme. Proglycogen may be an intermediate in the synthesis and degradation of macromolecular glycogen and may exist and be metabolized as a separate entity. Consideration should now be given to the revival of the concept that tissue contains two forms of glycogen. One is proglycogen. The other is the 'classical', macromolecular glycogen. Additionally, proglycogen and glycogen may be glucosylated by different forms of synthase.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalFEBS Letters
Volume279
Issue number2
DOIs
StatePublished - Feb 25 1991

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Glycogen
Muscle
Molecular Weight
Molecular weight
Muscles
Enzymes
Glucose
Glycogen Synthase
Trichloroacetic Acid
Names
Proteins
Tissue
Degradation
Molecules

Keywords

  • Glycogen biogenesis
  • Glycogenin
  • Proglycogen
  • Protein glucosylation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Proglycogen : A low-molecular-weight form of muscle glycogen. / Lomako, Joseph; Lomako, Wieslawa M.; Whelan, William J.

In: FEBS Letters, Vol. 279, No. 2, 25.02.1991, p. 223-228.

Research output: Contribution to journalArticle

Lomako, Joseph ; Lomako, Wieslawa M. ; Whelan, William J. / Proglycogen : A low-molecular-weight form of muscle glycogen. In: FEBS Letters. 1991 ; Vol. 279, No. 2. pp. 223-228.
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