Progestins and antiprogestins in mammary tumour growth and metastasis

Y. E. Shi, Y. E. Liu, Marc E Lippman, R. B. Dickson

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Growth of the normal mammary gland involves proliferation, differentiation, programmed cell death and remodelling of the basement membrane throughout the cyclic ovarian stimulation of the menstrual cycle and the pregnancy/lactation cycle. The regulation of these processes involves a balance between the actions of oestrogen and progesterone. Although it is generally accepted that oestrogens are the major adverse hormonal factor in onset and progression of human breast cancer, recent studies suggest that progesterone and its synthetic progestins may be more important than oestrogen as an ovarian stimulus in driving proliferation of normal human and rodent mammary epithelium. One might expect that some aspects of these complex progestin-regulated events might be retained in breast cancer. This review focuses on evidence that progesterone has proliferative actions in breast cancers; on the role of progestins in regulation of metastasis-related adhesion molecules on breast cancer cells and on the preliminary data showing that progesterone antagonists may be powerful new tools for the management of metastastic breast cancer. This evidence suggests that progesterone is a stimulus for onset and progression of breast tumours and that antiprogestins can interrupt these processes.

Original languageEnglish
Pages (from-to)162-173
Number of pages12
JournalHuman Reproduction
Volume9
Issue numberSUPPL. 1
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Progestins
Progesterone
Breast Neoplasms
Neoplasm Metastasis
Growth
Estrogens
Human Mammary Glands
Progesterone Congeners
Ovulation Induction
Menstrual Cycle
Lactation
Basement Membrane
Rodentia
Cell Death
Pregnancy

Keywords

  • Antiprogestins
  • Mammary
  • Metastasis
  • Progesterone
  • Progestins
  • Tumour

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Shi, Y. E., Liu, Y. E., Lippman, M. E., & Dickson, R. B. (1994). Progestins and antiprogestins in mammary tumour growth and metastasis. Human Reproduction, 9(SUPPL. 1), 162-173.

Progestins and antiprogestins in mammary tumour growth and metastasis. / Shi, Y. E.; Liu, Y. E.; Lippman, Marc E; Dickson, R. B.

In: Human Reproduction, Vol. 9, No. SUPPL. 1, 01.01.1994, p. 162-173.

Research output: Contribution to journalArticle

Shi, YE, Liu, YE, Lippman, ME & Dickson, RB 1994, 'Progestins and antiprogestins in mammary tumour growth and metastasis', Human Reproduction, vol. 9, no. SUPPL. 1, pp. 162-173.
Shi YE, Liu YE, Lippman ME, Dickson RB. Progestins and antiprogestins in mammary tumour growth and metastasis. Human Reproduction. 1994 Jan 1;9(SUPPL. 1):162-173.
Shi, Y. E. ; Liu, Y. E. ; Lippman, Marc E ; Dickson, R. B. / Progestins and antiprogestins in mammary tumour growth and metastasis. In: Human Reproduction. 1994 ; Vol. 9, No. SUPPL. 1. pp. 162-173.
@article{1d247497d2384539a059509387e5db00,
title = "Progestins and antiprogestins in mammary tumour growth and metastasis",
abstract = "Growth of the normal mammary gland involves proliferation, differentiation, programmed cell death and remodelling of the basement membrane throughout the cyclic ovarian stimulation of the menstrual cycle and the pregnancy/lactation cycle. The regulation of these processes involves a balance between the actions of oestrogen and progesterone. Although it is generally accepted that oestrogens are the major adverse hormonal factor in onset and progression of human breast cancer, recent studies suggest that progesterone and its synthetic progestins may be more important than oestrogen as an ovarian stimulus in driving proliferation of normal human and rodent mammary epithelium. One might expect that some aspects of these complex progestin-regulated events might be retained in breast cancer. This review focuses on evidence that progesterone has proliferative actions in breast cancers; on the role of progestins in regulation of metastasis-related adhesion molecules on breast cancer cells and on the preliminary data showing that progesterone antagonists may be powerful new tools for the management of metastastic breast cancer. This evidence suggests that progesterone is a stimulus for onset and progression of breast tumours and that antiprogestins can interrupt these processes.",
keywords = "Antiprogestins, Mammary, Metastasis, Progesterone, Progestins, Tumour",
author = "Shi, {Y. E.} and Liu, {Y. E.} and Lippman, {Marc E} and Dickson, {R. B.}",
year = "1994",
month = "1",
day = "1",
language = "English",
volume = "9",
pages = "162--173",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Progestins and antiprogestins in mammary tumour growth and metastasis

AU - Shi, Y. E.

AU - Liu, Y. E.

AU - Lippman, Marc E

AU - Dickson, R. B.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Growth of the normal mammary gland involves proliferation, differentiation, programmed cell death and remodelling of the basement membrane throughout the cyclic ovarian stimulation of the menstrual cycle and the pregnancy/lactation cycle. The regulation of these processes involves a balance between the actions of oestrogen and progesterone. Although it is generally accepted that oestrogens are the major adverse hormonal factor in onset and progression of human breast cancer, recent studies suggest that progesterone and its synthetic progestins may be more important than oestrogen as an ovarian stimulus in driving proliferation of normal human and rodent mammary epithelium. One might expect that some aspects of these complex progestin-regulated events might be retained in breast cancer. This review focuses on evidence that progesterone has proliferative actions in breast cancers; on the role of progestins in regulation of metastasis-related adhesion molecules on breast cancer cells and on the preliminary data showing that progesterone antagonists may be powerful new tools for the management of metastastic breast cancer. This evidence suggests that progesterone is a stimulus for onset and progression of breast tumours and that antiprogestins can interrupt these processes.

AB - Growth of the normal mammary gland involves proliferation, differentiation, programmed cell death and remodelling of the basement membrane throughout the cyclic ovarian stimulation of the menstrual cycle and the pregnancy/lactation cycle. The regulation of these processes involves a balance between the actions of oestrogen and progesterone. Although it is generally accepted that oestrogens are the major adverse hormonal factor in onset and progression of human breast cancer, recent studies suggest that progesterone and its synthetic progestins may be more important than oestrogen as an ovarian stimulus in driving proliferation of normal human and rodent mammary epithelium. One might expect that some aspects of these complex progestin-regulated events might be retained in breast cancer. This review focuses on evidence that progesterone has proliferative actions in breast cancers; on the role of progestins in regulation of metastasis-related adhesion molecules on breast cancer cells and on the preliminary data showing that progesterone antagonists may be powerful new tools for the management of metastastic breast cancer. This evidence suggests that progesterone is a stimulus for onset and progression of breast tumours and that antiprogestins can interrupt these processes.

KW - Antiprogestins

KW - Mammary

KW - Metastasis

KW - Progesterone

KW - Progestins

KW - Tumour

UR - http://www.scopus.com/inward/record.url?scp=0028301211&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028301211&partnerID=8YFLogxK

M3 - Article

C2 - 7962461

AN - SCOPUS:0028301211

VL - 9

SP - 162

EP - 173

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - SUPPL. 1

ER -