Production of early and late pulmonary responses with inhaled leukotriene D4 in allergic sheep

W. M. Abraham, E. Russi, Adam Wanner, J. C. Delehunt, L. D. Yerger, G. A. Chapman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Some allergic sheep respond to inhalation of Ascaris suum antigen with both immediate and late increases in airflow resistance (late response). The mechanism of the late response is unknown but recent evidence suggests that the initial generation of slow-reacting substance of anaphylaxis (SRS-A) immediately after antigen challenge is a necessary pre-requisite for the physiologic expression of this late response. Based on this evidence we hypothesized that airway challenge with leukotriene D4 (LTD4), an active component of SRS-A would produce acute and late airway responses in allergic sheep similar to those observed with antigen. In five allergic sheep with documented early and late pulmonary responses to Ascaris suum antigen, inhalation of leukotriene D4 aerosol (delivered dose [mean ± SE] 0.55 ± 0.08 ug) resulted in significant early and late increases in specific lung resistance [SR(L)]. In three allergic sheep which only demonstrated acute responses to antigen, LTD4 aerosol (delivered dose 0.59 ± 0.09 ug) only produced an acute increase in SR(L). In the late responders pretreatment with aerosol cromolyn sodium (1 mg/kg) did not affect the acute response but blunted the late increase in SR(L). Pretreatment with aerosol FPL-57231 (1% w/v solution) completely blocked both the acute and late responses. These data support the hypothesis that initial release of LTD4 in the airways of sensitive animals is important for the physiologic expression of the late response.

Original languageEnglish
Pages (from-to)715-726
Number of pages12
JournalProstaglandins
Volume29
Issue number5
DOIs
StatePublished - Nov 6 1985

Fingerprint

Leukotriene D4
Sheep
Aerosols
Antigens
Lung
SRS-A
Ascaris suum
Inhalation
Cromolyn Sodium
Animals

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Production of early and late pulmonary responses with inhaled leukotriene D4 in allergic sheep. / Abraham, W. M.; Russi, E.; Wanner, Adam; Delehunt, J. C.; Yerger, L. D.; Chapman, G. A.

In: Prostaglandins, Vol. 29, No. 5, 06.11.1985, p. 715-726.

Research output: Contribution to journalArticle

Abraham, W. M. ; Russi, E. ; Wanner, Adam ; Delehunt, J. C. ; Yerger, L. D. ; Chapman, G. A. / Production of early and late pulmonary responses with inhaled leukotriene D4 in allergic sheep. In: Prostaglandins. 1985 ; Vol. 29, No. 5. pp. 715-726.
@article{51374b1b5c7b4b7ea09549915c0e880b,
title = "Production of early and late pulmonary responses with inhaled leukotriene D4 in allergic sheep",
abstract = "Some allergic sheep respond to inhalation of Ascaris suum antigen with both immediate and late increases in airflow resistance (late response). The mechanism of the late response is unknown but recent evidence suggests that the initial generation of slow-reacting substance of anaphylaxis (SRS-A) immediately after antigen challenge is a necessary pre-requisite for the physiologic expression of this late response. Based on this evidence we hypothesized that airway challenge with leukotriene D4 (LTD4), an active component of SRS-A would produce acute and late airway responses in allergic sheep similar to those observed with antigen. In five allergic sheep with documented early and late pulmonary responses to Ascaris suum antigen, inhalation of leukotriene D4 aerosol (delivered dose [mean ± SE] 0.55 ± 0.08 ug) resulted in significant early and late increases in specific lung resistance [SR(L)]. In three allergic sheep which only demonstrated acute responses to antigen, LTD4 aerosol (delivered dose 0.59 ± 0.09 ug) only produced an acute increase in SR(L). In the late responders pretreatment with aerosol cromolyn sodium (1 mg/kg) did not affect the acute response but blunted the late increase in SR(L). Pretreatment with aerosol FPL-57231 (1{\%} w/v solution) completely blocked both the acute and late responses. These data support the hypothesis that initial release of LTD4 in the airways of sensitive animals is important for the physiologic expression of the late response.",
author = "Abraham, {W. M.} and E. Russi and Adam Wanner and Delehunt, {J. C.} and Yerger, {L. D.} and Chapman, {G. A.}",
year = "1985",
month = "11",
day = "6",
doi = "10.1016/0304-3940(84)90205-2",
language = "English",
volume = "29",
pages = "715--726",
journal = "Prostaglandins",
issn = "0090-6980",
publisher = "Elsevier BV",
number = "5",

}

TY - JOUR

T1 - Production of early and late pulmonary responses with inhaled leukotriene D4 in allergic sheep

AU - Abraham, W. M.

AU - Russi, E.

AU - Wanner, Adam

AU - Delehunt, J. C.

AU - Yerger, L. D.

AU - Chapman, G. A.

PY - 1985/11/6

Y1 - 1985/11/6

N2 - Some allergic sheep respond to inhalation of Ascaris suum antigen with both immediate and late increases in airflow resistance (late response). The mechanism of the late response is unknown but recent evidence suggests that the initial generation of slow-reacting substance of anaphylaxis (SRS-A) immediately after antigen challenge is a necessary pre-requisite for the physiologic expression of this late response. Based on this evidence we hypothesized that airway challenge with leukotriene D4 (LTD4), an active component of SRS-A would produce acute and late airway responses in allergic sheep similar to those observed with antigen. In five allergic sheep with documented early and late pulmonary responses to Ascaris suum antigen, inhalation of leukotriene D4 aerosol (delivered dose [mean ± SE] 0.55 ± 0.08 ug) resulted in significant early and late increases in specific lung resistance [SR(L)]. In three allergic sheep which only demonstrated acute responses to antigen, LTD4 aerosol (delivered dose 0.59 ± 0.09 ug) only produced an acute increase in SR(L). In the late responders pretreatment with aerosol cromolyn sodium (1 mg/kg) did not affect the acute response but blunted the late increase in SR(L). Pretreatment with aerosol FPL-57231 (1% w/v solution) completely blocked both the acute and late responses. These data support the hypothesis that initial release of LTD4 in the airways of sensitive animals is important for the physiologic expression of the late response.

AB - Some allergic sheep respond to inhalation of Ascaris suum antigen with both immediate and late increases in airflow resistance (late response). The mechanism of the late response is unknown but recent evidence suggests that the initial generation of slow-reacting substance of anaphylaxis (SRS-A) immediately after antigen challenge is a necessary pre-requisite for the physiologic expression of this late response. Based on this evidence we hypothesized that airway challenge with leukotriene D4 (LTD4), an active component of SRS-A would produce acute and late airway responses in allergic sheep similar to those observed with antigen. In five allergic sheep with documented early and late pulmonary responses to Ascaris suum antigen, inhalation of leukotriene D4 aerosol (delivered dose [mean ± SE] 0.55 ± 0.08 ug) resulted in significant early and late increases in specific lung resistance [SR(L)]. In three allergic sheep which only demonstrated acute responses to antigen, LTD4 aerosol (delivered dose 0.59 ± 0.09 ug) only produced an acute increase in SR(L). In the late responders pretreatment with aerosol cromolyn sodium (1 mg/kg) did not affect the acute response but blunted the late increase in SR(L). Pretreatment with aerosol FPL-57231 (1% w/v solution) completely blocked both the acute and late responses. These data support the hypothesis that initial release of LTD4 in the airways of sensitive animals is important for the physiologic expression of the late response.

UR - http://www.scopus.com/inward/record.url?scp=84886641667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886641667&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(84)90205-2

DO - 10.1016/0304-3940(84)90205-2

M3 - Article

C2 - 3925500

AN - SCOPUS:84886641667

VL - 29

SP - 715

EP - 726

JO - Prostaglandins

JF - Prostaglandins

SN - 0090-6980

IS - 5

ER -