Abstract
Chronic hepatitis develops in at least half of persons acutely infected with hepatitis C virus (HCV). Ten to 25 % of these patients will develop cirrhosis. Serum procollagen-III peptide (PIIIP) may be of value in predicting the development of chronic active fibrogenic liver disease. It has been reported that in chronic viral C hepatitis, the levels of hepatitis C virus-RNA (HCV-RNA) correlate directly with the severity of hepatic histology and inversely with response to interferon therapy. Objectives: The aims of this study were to correlate the level of PIIIP with HCV-RNA concentrations, ALT values, and histological severity in patients with chronic viral C hepatitis. Methods: Eighty-six patients with chronic C hepatitis were divided into three groups: group I (n = 34), mild chronic active hepatitis, group II (n = 25), moderate to severe chronic active hepatitis, and group III (n = 27), cirrhosis. HCV-RNA was measured by Quantiplex, and PIIIP was measured by radioimmunoassay-gnostic assay. Results: Mean ± SD level of ALT in group I was 114 ± 48 U/L, group II was 169 ± 115 U/L, and group III was 160 ± 94 U/L. The mean ± SD level of HCV-RNA in group I was 110 ± 130 x 105 Eq/ml, in group II was 140 ± 140 x 105 Eq/ml, and in group III was 70 ± 80 x 105 Eq/ml. The mean ± SD level of PIIIP in group I was 0.6 ± 0.2 U/ml, in group II was 0.9 ± 0.4 U/ml, and in group III was 1.2 ± 0.6. There was a significant difference in the levels of PIIIP among the three groups (p = 0.0001). There was no correlation among ALT, HCV-RNA, and PIIIP in any of the three groups. Conclusions: PIIIP peptide determinations in patients with chronic viral C hepatitis are reflective of histological severity and may provide relatively noninvasive means of following disease progression.
| Original language | English |
|---|---|
| Pages (from-to) | 1437-1440 |
| Number of pages | 4 |
| Journal | American Journal of Gastroenterology |
| Volume | 90 |
| Issue number | 9 |
| State | Published - Jan 1 1995 |
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ASJC Scopus subject areas
- Gastroenterology
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Procollagen-III peptide and chronic viral C hepatitis. / Jeffers, Lennox J; Coelho-Little, M. E.; Cheinquer, H.; Vargas, C.; Civantos, Francisco; Alvarez, L.; Reddy, K. R.; Parker, T.; De Medina, M.; Li, X.; Hill, M.; LaRue, S.; Schiff, Eugene R.
In: American Journal of Gastroenterology, Vol. 90, No. 9, 01.01.1995, p. 1437-1440.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Procollagen-III peptide and chronic viral C hepatitis
AU - Jeffers, Lennox J
AU - Coelho-Little, M. E.
AU - Cheinquer, H.
AU - Vargas, C.
AU - Civantos, Francisco
AU - Alvarez, L.
AU - Reddy, K. R.
AU - Parker, T.
AU - De Medina, M.
AU - Li, X.
AU - Hill, M.
AU - LaRue, S.
AU - Schiff, Eugene R
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Chronic hepatitis develops in at least half of persons acutely infected with hepatitis C virus (HCV). Ten to 25 % of these patients will develop cirrhosis. Serum procollagen-III peptide (PIIIP) may be of value in predicting the development of chronic active fibrogenic liver disease. It has been reported that in chronic viral C hepatitis, the levels of hepatitis C virus-RNA (HCV-RNA) correlate directly with the severity of hepatic histology and inversely with response to interferon therapy. Objectives: The aims of this study were to correlate the level of PIIIP with HCV-RNA concentrations, ALT values, and histological severity in patients with chronic viral C hepatitis. Methods: Eighty-six patients with chronic C hepatitis were divided into three groups: group I (n = 34), mild chronic active hepatitis, group II (n = 25), moderate to severe chronic active hepatitis, and group III (n = 27), cirrhosis. HCV-RNA was measured by Quantiplex, and PIIIP was measured by radioimmunoassay-gnostic assay. Results: Mean ± SD level of ALT in group I was 114 ± 48 U/L, group II was 169 ± 115 U/L, and group III was 160 ± 94 U/L. The mean ± SD level of HCV-RNA in group I was 110 ± 130 x 105 Eq/ml, in group II was 140 ± 140 x 105 Eq/ml, and in group III was 70 ± 80 x 105 Eq/ml. The mean ± SD level of PIIIP in group I was 0.6 ± 0.2 U/ml, in group II was 0.9 ± 0.4 U/ml, and in group III was 1.2 ± 0.6. There was a significant difference in the levels of PIIIP among the three groups (p = 0.0001). There was no correlation among ALT, HCV-RNA, and PIIIP in any of the three groups. Conclusions: PIIIP peptide determinations in patients with chronic viral C hepatitis are reflective of histological severity and may provide relatively noninvasive means of following disease progression.
AB - Chronic hepatitis develops in at least half of persons acutely infected with hepatitis C virus (HCV). Ten to 25 % of these patients will develop cirrhosis. Serum procollagen-III peptide (PIIIP) may be of value in predicting the development of chronic active fibrogenic liver disease. It has been reported that in chronic viral C hepatitis, the levels of hepatitis C virus-RNA (HCV-RNA) correlate directly with the severity of hepatic histology and inversely with response to interferon therapy. Objectives: The aims of this study were to correlate the level of PIIIP with HCV-RNA concentrations, ALT values, and histological severity in patients with chronic viral C hepatitis. Methods: Eighty-six patients with chronic C hepatitis were divided into three groups: group I (n = 34), mild chronic active hepatitis, group II (n = 25), moderate to severe chronic active hepatitis, and group III (n = 27), cirrhosis. HCV-RNA was measured by Quantiplex, and PIIIP was measured by radioimmunoassay-gnostic assay. Results: Mean ± SD level of ALT in group I was 114 ± 48 U/L, group II was 169 ± 115 U/L, and group III was 160 ± 94 U/L. The mean ± SD level of HCV-RNA in group I was 110 ± 130 x 105 Eq/ml, in group II was 140 ± 140 x 105 Eq/ml, and in group III was 70 ± 80 x 105 Eq/ml. The mean ± SD level of PIIIP in group I was 0.6 ± 0.2 U/ml, in group II was 0.9 ± 0.4 U/ml, and in group III was 1.2 ± 0.6. There was a significant difference in the levels of PIIIP among the three groups (p = 0.0001). There was no correlation among ALT, HCV-RNA, and PIIIP in any of the three groups. Conclusions: PIIIP peptide determinations in patients with chronic viral C hepatitis are reflective of histological severity and may provide relatively noninvasive means of following disease progression.
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M3 - Article
C2 - 7661165
AN - SCOPUS:0029117737
VL - 90
SP - 1437
EP - 1440
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
SN - 0002-9270
IS - 9
ER -