Procollagen-III peptide and chronic viral C hepatitis

Lennox J Jeffers, M. E. Coelho-Little, H. Cheinquer, C. Vargas, Francisco Civantos, L. Alvarez, K. R. Reddy, T. Parker, M. De Medina, X. Li, M. Hill, S. LaRue, Eugene R Schiff

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Abstract

Chronic hepatitis develops in at least half of persons acutely infected with hepatitis C virus (HCV). Ten to 25 % of these patients will develop cirrhosis. Serum procollagen-III peptide (PIIIP) may be of value in predicting the development of chronic active fibrogenic liver disease. It has been reported that in chronic viral C hepatitis, the levels of hepatitis C virus-RNA (HCV-RNA) correlate directly with the severity of hepatic histology and inversely with response to interferon therapy. Objectives: The aims of this study were to correlate the level of PIIIP with HCV-RNA concentrations, ALT values, and histological severity in patients with chronic viral C hepatitis. Methods: Eighty-six patients with chronic C hepatitis were divided into three groups: group I (n = 34), mild chronic active hepatitis, group II (n = 25), moderate to severe chronic active hepatitis, and group III (n = 27), cirrhosis. HCV-RNA was measured by Quantiplex, and PIIIP was measured by radioimmunoassay-gnostic assay. Results: Mean ± SD level of ALT in group I was 114 ± 48 U/L, group II was 169 ± 115 U/L, and group III was 160 ± 94 U/L. The mean ± SD level of HCV-RNA in group I was 110 ± 130 x 105 Eq/ml, in group II was 140 ± 140 x 105 Eq/ml, and in group III was 70 ± 80 x 105 Eq/ml. The mean ± SD level of PIIIP in group I was 0.6 ± 0.2 U/ml, in group II was 0.9 ± 0.4 U/ml, and in group III was 1.2 ± 0.6. There was a significant difference in the levels of PIIIP among the three groups (p = 0.0001). There was no correlation among ALT, HCV-RNA, and PIIIP in any of the three groups. Conclusions: PIIIP peptide determinations in patients with chronic viral C hepatitis are reflective of histological severity and may provide relatively noninvasive means of following disease progression.

Original languageEnglish
Pages (from-to)1437-1440
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume90
Issue number9
StatePublished - Jan 1 1995

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Procollagen
Chronic Hepatitis C
Hepacivirus
Peptides
RNA
Chronic Hepatitis
Fibrosis
Interferons
Radioimmunoassay
Disease Progression
Liver Diseases
Histology
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Jeffers, L. J., Coelho-Little, M. E., Cheinquer, H., Vargas, C., Civantos, F., Alvarez, L., ... Schiff, E. R. (1995). Procollagen-III peptide and chronic viral C hepatitis. American Journal of Gastroenterology, 90(9), 1437-1440.

Procollagen-III peptide and chronic viral C hepatitis. / Jeffers, Lennox J; Coelho-Little, M. E.; Cheinquer, H.; Vargas, C.; Civantos, Francisco; Alvarez, L.; Reddy, K. R.; Parker, T.; De Medina, M.; Li, X.; Hill, M.; LaRue, S.; Schiff, Eugene R.

In: American Journal of Gastroenterology, Vol. 90, No. 9, 01.01.1995, p. 1437-1440.

Research output: Contribution to journalArticle

Jeffers, LJ, Coelho-Little, ME, Cheinquer, H, Vargas, C, Civantos, F, Alvarez, L, Reddy, KR, Parker, T, De Medina, M, Li, X, Hill, M, LaRue, S & Schiff, ER 1995, 'Procollagen-III peptide and chronic viral C hepatitis', American Journal of Gastroenterology, vol. 90, no. 9, pp. 1437-1440.
Jeffers LJ, Coelho-Little ME, Cheinquer H, Vargas C, Civantos F, Alvarez L et al. Procollagen-III peptide and chronic viral C hepatitis. American Journal of Gastroenterology. 1995 Jan 1;90(9):1437-1440.
Jeffers, Lennox J ; Coelho-Little, M. E. ; Cheinquer, H. ; Vargas, C. ; Civantos, Francisco ; Alvarez, L. ; Reddy, K. R. ; Parker, T. ; De Medina, M. ; Li, X. ; Hill, M. ; LaRue, S. ; Schiff, Eugene R. / Procollagen-III peptide and chronic viral C hepatitis. In: American Journal of Gastroenterology. 1995 ; Vol. 90, No. 9. pp. 1437-1440.
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title = "Procollagen-III peptide and chronic viral C hepatitis",
abstract = "Chronic hepatitis develops in at least half of persons acutely infected with hepatitis C virus (HCV). Ten to 25 {\%} of these patients will develop cirrhosis. Serum procollagen-III peptide (PIIIP) may be of value in predicting the development of chronic active fibrogenic liver disease. It has been reported that in chronic viral C hepatitis, the levels of hepatitis C virus-RNA (HCV-RNA) correlate directly with the severity of hepatic histology and inversely with response to interferon therapy. Objectives: The aims of this study were to correlate the level of PIIIP with HCV-RNA concentrations, ALT values, and histological severity in patients with chronic viral C hepatitis. Methods: Eighty-six patients with chronic C hepatitis were divided into three groups: group I (n = 34), mild chronic active hepatitis, group II (n = 25), moderate to severe chronic active hepatitis, and group III (n = 27), cirrhosis. HCV-RNA was measured by Quantiplex, and PIIIP was measured by radioimmunoassay-gnostic assay. Results: Mean ± SD level of ALT in group I was 114 ± 48 U/L, group II was 169 ± 115 U/L, and group III was 160 ± 94 U/L. The mean ± SD level of HCV-RNA in group I was 110 ± 130 x 105 Eq/ml, in group II was 140 ± 140 x 105 Eq/ml, and in group III was 70 ± 80 x 105 Eq/ml. The mean ± SD level of PIIIP in group I was 0.6 ± 0.2 U/ml, in group II was 0.9 ± 0.4 U/ml, and in group III was 1.2 ± 0.6. There was a significant difference in the levels of PIIIP among the three groups (p = 0.0001). There was no correlation among ALT, HCV-RNA, and PIIIP in any of the three groups. Conclusions: PIIIP peptide determinations in patients with chronic viral C hepatitis are reflective of histological severity and may provide relatively noninvasive means of following disease progression.",
author = "Jeffers, {Lennox J} and Coelho-Little, {M. E.} and H. Cheinquer and C. Vargas and Francisco Civantos and L. Alvarez and Reddy, {K. R.} and T. Parker and {De Medina}, M. and X. Li and M. Hill and S. LaRue and Schiff, {Eugene R}",
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T1 - Procollagen-III peptide and chronic viral C hepatitis

AU - Jeffers, Lennox J

AU - Coelho-Little, M. E.

AU - Cheinquer, H.

AU - Vargas, C.

AU - Civantos, Francisco

AU - Alvarez, L.

AU - Reddy, K. R.

AU - Parker, T.

AU - De Medina, M.

AU - Li, X.

AU - Hill, M.

AU - LaRue, S.

AU - Schiff, Eugene R

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Chronic hepatitis develops in at least half of persons acutely infected with hepatitis C virus (HCV). Ten to 25 % of these patients will develop cirrhosis. Serum procollagen-III peptide (PIIIP) may be of value in predicting the development of chronic active fibrogenic liver disease. It has been reported that in chronic viral C hepatitis, the levels of hepatitis C virus-RNA (HCV-RNA) correlate directly with the severity of hepatic histology and inversely with response to interferon therapy. Objectives: The aims of this study were to correlate the level of PIIIP with HCV-RNA concentrations, ALT values, and histological severity in patients with chronic viral C hepatitis. Methods: Eighty-six patients with chronic C hepatitis were divided into three groups: group I (n = 34), mild chronic active hepatitis, group II (n = 25), moderate to severe chronic active hepatitis, and group III (n = 27), cirrhosis. HCV-RNA was measured by Quantiplex, and PIIIP was measured by radioimmunoassay-gnostic assay. Results: Mean ± SD level of ALT in group I was 114 ± 48 U/L, group II was 169 ± 115 U/L, and group III was 160 ± 94 U/L. The mean ± SD level of HCV-RNA in group I was 110 ± 130 x 105 Eq/ml, in group II was 140 ± 140 x 105 Eq/ml, and in group III was 70 ± 80 x 105 Eq/ml. The mean ± SD level of PIIIP in group I was 0.6 ± 0.2 U/ml, in group II was 0.9 ± 0.4 U/ml, and in group III was 1.2 ± 0.6. There was a significant difference in the levels of PIIIP among the three groups (p = 0.0001). There was no correlation among ALT, HCV-RNA, and PIIIP in any of the three groups. Conclusions: PIIIP peptide determinations in patients with chronic viral C hepatitis are reflective of histological severity and may provide relatively noninvasive means of following disease progression.

AB - Chronic hepatitis develops in at least half of persons acutely infected with hepatitis C virus (HCV). Ten to 25 % of these patients will develop cirrhosis. Serum procollagen-III peptide (PIIIP) may be of value in predicting the development of chronic active fibrogenic liver disease. It has been reported that in chronic viral C hepatitis, the levels of hepatitis C virus-RNA (HCV-RNA) correlate directly with the severity of hepatic histology and inversely with response to interferon therapy. Objectives: The aims of this study were to correlate the level of PIIIP with HCV-RNA concentrations, ALT values, and histological severity in patients with chronic viral C hepatitis. Methods: Eighty-six patients with chronic C hepatitis were divided into three groups: group I (n = 34), mild chronic active hepatitis, group II (n = 25), moderate to severe chronic active hepatitis, and group III (n = 27), cirrhosis. HCV-RNA was measured by Quantiplex, and PIIIP was measured by radioimmunoassay-gnostic assay. Results: Mean ± SD level of ALT in group I was 114 ± 48 U/L, group II was 169 ± 115 U/L, and group III was 160 ± 94 U/L. The mean ± SD level of HCV-RNA in group I was 110 ± 130 x 105 Eq/ml, in group II was 140 ± 140 x 105 Eq/ml, and in group III was 70 ± 80 x 105 Eq/ml. The mean ± SD level of PIIIP in group I was 0.6 ± 0.2 U/ml, in group II was 0.9 ± 0.4 U/ml, and in group III was 1.2 ± 0.6. There was a significant difference in the levels of PIIIP among the three groups (p = 0.0001). There was no correlation among ALT, HCV-RNA, and PIIIP in any of the three groups. Conclusions: PIIIP peptide determinations in patients with chronic viral C hepatitis are reflective of histological severity and may provide relatively noninvasive means of following disease progression.

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