Processing of tRNA in prokaryotes and eukaryotes.

Murray P Deutscher

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Considerable progress has been made in defining the steps in the conversion of a tRNA precursor to a mature tRNA. These steps, which differ in different systems, include removal of precursor-specific residues from the 5' and 3' termini of the initial transcript, addition of the 3'-C-C-A terminus, splicing of intervening sequences, and modification of nucleotide residues. Despite these advances in defining the "pathways" of tRNA processing, relatively little is known about most of the enzymes actually involved in these processing steps. In this article I describe the sequence of reactions needed to convert the initial tRNA transcript to a functional, mature tRNA, and discuss the specificity and properties of enzymes known to be involved in this process. In addition, I speculate on the expected specificities of other enzymes involved in tRNA processing which have not yet been identified, and on the structural organization of the processing machinery.

Original languageEnglish
Pages (from-to)45-71
Number of pages27
JournalCRC critical reviews in biochemistry
Volume17
Issue number1
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Transfer RNA
Eukaryota
Processing
Enzymes
RNA Precursors
Introns
Machinery
Nucleotides

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Biochemistry

Cite this

Processing of tRNA in prokaryotes and eukaryotes. / Deutscher, Murray P.

In: CRC critical reviews in biochemistry, Vol. 17, No. 1, 01.01.1984, p. 45-71.

Research output: Contribution to journalArticle

Deutscher, Murray P. / Processing of tRNA in prokaryotes and eukaryotes. In: CRC critical reviews in biochemistry. 1984 ; Vol. 17, No. 1. pp. 45-71.
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