Procainamide elimination kinetics in pediatric patients

Sharanjeet Singh, Henry Gelband, Ashok V. Mehta, Kenneth Kessler, Alfonso Casta, Arthur S. Pickoff

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Procainamide kinetics were studied in six children after a single intravenous dose. Two-compartment kinetic analysis of serum concentration-time curves of five children, who received a dose of 5.5 ± 0.9 mg/kg (mean ± SD), revealed the following values for kinetic parameters: distribution half-life, 10.3 ± 3.4 min; elimination half-life, 1.7 ± 0.1 hr; elimination constant, 1.2 ± 0.3 hr-1; plasma clearance 19.4 ± 2.0 ml/min/kg, and steady-state volume of distribution, 2.2 ± 0.3 l/kg. A sixth patient, who received an accidental overdose of 28 mg/kg, had altered elimination kinetics due to drug-induced hypotension. N-acetylprocainamide (NAPA) was detected in serum samples obtained soon after procainamide dosing and peak concentrations were attained at 1 to 2 hr. NAPA levels were lower than corresponding procainamide concentrations at most sampling periods. The findings of short elimination half-life and rapid plasma clearance of procainamide in children suggest that continuous intravenous infusion may be necessary to maintain therapeutically effective plasma concentrations in these patients.

Original languageEnglish (US)
Pages (from-to)607-611
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume32
Issue number5
DOIs
StatePublished - Nov 1982
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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