TY - JOUR
T1 - Procainamide elimination kinetics in pediatric patients
AU - Singh, Sharanjeet
AU - Gelband, Henry
AU - Mehta, Ashok V.
AU - Kessler, Kenneth
AU - Casta, Alfonso
AU - Pickoff, Arthur S.
PY - 1982/11
Y1 - 1982/11
N2 - Procainamide kinetics were studied in six children after a single intravenous dose. Two-compartment kinetic analysis of serum concentration-time curves of five children, who received a dose of 5.5 ± 0.9 mg/kg (mean ± SD), revealed the following values for kinetic parameters: distribution half-life, 10.3 ± 3.4 min; elimination half-life, 1.7 ± 0.1 hr; elimination constant, 1.2 ± 0.3 hr-1; plasma clearance 19.4 ± 2.0 ml/min/kg, and steady-state volume of distribution, 2.2 ± 0.3 l/kg. A sixth patient, who received an accidental overdose of 28 mg/kg, had altered elimination kinetics due to drug-induced hypotension. N-acetylprocainamide (NAPA) was detected in serum samples obtained soon after procainamide dosing and peak concentrations were attained at 1 to 2 hr. NAPA levels were lower than corresponding procainamide concentrations at most sampling periods. The findings of short elimination half-life and rapid plasma clearance of procainamide in children suggest that continuous intravenous infusion may be necessary to maintain therapeutically effective plasma concentrations in these patients.
AB - Procainamide kinetics were studied in six children after a single intravenous dose. Two-compartment kinetic analysis of serum concentration-time curves of five children, who received a dose of 5.5 ± 0.9 mg/kg (mean ± SD), revealed the following values for kinetic parameters: distribution half-life, 10.3 ± 3.4 min; elimination half-life, 1.7 ± 0.1 hr; elimination constant, 1.2 ± 0.3 hr-1; plasma clearance 19.4 ± 2.0 ml/min/kg, and steady-state volume of distribution, 2.2 ± 0.3 l/kg. A sixth patient, who received an accidental overdose of 28 mg/kg, had altered elimination kinetics due to drug-induced hypotension. N-acetylprocainamide (NAPA) was detected in serum samples obtained soon after procainamide dosing and peak concentrations were attained at 1 to 2 hr. NAPA levels were lower than corresponding procainamide concentrations at most sampling periods. The findings of short elimination half-life and rapid plasma clearance of procainamide in children suggest that continuous intravenous infusion may be necessary to maintain therapeutically effective plasma concentrations in these patients.
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U2 - 10.1038/clpt.1982.210
DO - 10.1038/clpt.1982.210
M3 - Article
C2 - 7128001
AN - SCOPUS:0020287065
VL - 32
SP - 607
EP - 611
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 5
ER -