Probucol enhances cholesterol efflux from cultured human skin fibroblasts

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

To explore whether the reported xanthoma-reducting effects of probucol are related to tissue-specific mechanisms of the drug, the influence of probucol on cholesterol efflux from cultured human skin fibroblasts was investigated. Incubation of cells with probucol led to a 2-fold enhancement of high-density lipoprotein-mediated cholesterol efflux. This result raises the possibility that probucol may reduce cholesterol accumulation in tissues through a cholesterol-mobilizing action.

Original languageEnglish (US)
Pages (from-to)B57-B59
JournalThe American Journal of Cardiology
Volume62
Issue number3
DOIs
StatePublished - Jul 25 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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