Probucol enhances cholesterol efflux from cultured human skin fibroblasts

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Abstract

To explore whether the reported xanthoma-reducting effects of probucol are related to tissue-specific mechanisms of the drug, the influence of probucol on cholesterol efflux from cultured human skin fibroblasts was investigated. Incubation of cells with probucol led to a 2-fold enhancement of high-density lipoprotein-mediated cholesterol efflux. This result raises the possibility that probucol may reduce cholesterol accumulation in tissues through a cholesterol-mobilizing action.

Original languageEnglish
JournalThe American journal of cardiology
Volume62
Issue number3
DOIs
StatePublished - Jul 25 1988

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Probucol
Fibroblasts
Cholesterol
Skin
Xanthomatosis
HDL Cholesterol
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Probucol enhances cholesterol efflux from cultured human skin fibroblasts",
abstract = "To explore whether the reported xanthoma-reducting effects of probucol are related to tissue-specific mechanisms of the drug, the influence of probucol on cholesterol efflux from cultured human skin fibroblasts was investigated. Incubation of cells with probucol led to a 2-fold enhancement of high-density lipoprotein-mediated cholesterol efflux. This result raises the possibility that probucol may reduce cholesterol accumulation in tissues through a cholesterol-mobilizing action.",
author = "Goldberg, {Ronald B} and Mendez, {Armando J}",
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AB - To explore whether the reported xanthoma-reducting effects of probucol are related to tissue-specific mechanisms of the drug, the influence of probucol on cholesterol efflux from cultured human skin fibroblasts was investigated. Incubation of cells with probucol led to a 2-fold enhancement of high-density lipoprotein-mediated cholesterol efflux. This result raises the possibility that probucol may reduce cholesterol accumulation in tissues through a cholesterol-mobilizing action.

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