Problems with currently available antidepressants

Jane F. Gumnick, Charles B. Nemeroff

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations


Although options for pharmacologic treatment for depression have grown seemingly exponentially over the past several decades, the current armamentarium of antidepressants continues to have limitations of both efficacy and tolerability. The problems include an unacceptable lack of efficacy, delayed onset of therapeutic effects, an inability to predict responses to one or another agent, drug-drug interactions, and difficulty with tolerability during both acute and chronic treatment. This article reviews the problems that persist in the use of currently available antidepressant medications and presents a list of attributes that would be characteristic of the ideal antidepressant.

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalJournal of Clinical Psychiatry
Issue numberSUPPL. 10
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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