Problems with currently available antidepressants

Jane F. Gumnick, Charles Nemeroff

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Although options for pharmacologic treatment for depression have grown seemingly exponentially over the past several decades, the current armamentarium of antidepressants continues to have limitations of both efficacy and tolerability. The problems include an unacceptable lack of efficacy, delayed onset of therapeutic effects, an inability to predict responses to one or another agent, drug-drug interactions, and difficulty with tolerability during both acute and chronic treatment. This article reviews the problems that persist in the use of currently available antidepressant medications and presents a list of attributes that would be characteristic of the ideal antidepressant.

Original languageEnglish
Pages (from-to)5-15
Number of pages11
JournalJournal of Clinical Psychiatry
Volume61
Issue numberSUPPL. 10
StatePublished - Aug 7 2000
Externally publishedYes

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Antidepressive Agents
Therapeutic Uses
Drug Interactions
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Problems with currently available antidepressants. / Gumnick, Jane F.; Nemeroff, Charles.

In: Journal of Clinical Psychiatry, Vol. 61, No. SUPPL. 10, 07.08.2000, p. 5-15.

Research output: Contribution to journalArticle

Gumnick, Jane F. ; Nemeroff, Charles. / Problems with currently available antidepressants. In: Journal of Clinical Psychiatry. 2000 ; Vol. 61, No. SUPPL. 10. pp. 5-15.
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