Abstract
Although options for pharmacologic treatment for depression have grown seemingly exponentially over the past several decades, the current armamentarium of antidepressants continues to have limitations of both efficacy and tolerability. The problems include an unacceptable lack of efficacy, delayed onset of therapeutic effects, an inability to predict responses to one or another agent, drug-drug interactions, and difficulty with tolerability during both acute and chronic treatment. This article reviews the problems that persist in the use of currently available antidepressant medications and presents a list of attributes that would be characteristic of the ideal antidepressant.
| Original language | English |
|---|---|
| Pages (from-to) | 5-15 |
| Number of pages | 11 |
| Journal | Journal of Clinical Psychiatry |
| Volume | 61 |
| Issue number | SUPPL. 10 |
| State | Published - Aug 7 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Problems with currently available antidepressants. / Gumnick, Jane F.; Nemeroff, Charles.
In: Journal of Clinical Psychiatry, Vol. 61, No. SUPPL. 10, 07.08.2000, p. 5-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Problems with currently available antidepressants
AU - Gumnick, Jane F.
AU - Nemeroff, Charles
PY - 2000/8/7
Y1 - 2000/8/7
N2 - Although options for pharmacologic treatment for depression have grown seemingly exponentially over the past several decades, the current armamentarium of antidepressants continues to have limitations of both efficacy and tolerability. The problems include an unacceptable lack of efficacy, delayed onset of therapeutic effects, an inability to predict responses to one or another agent, drug-drug interactions, and difficulty with tolerability during both acute and chronic treatment. This article reviews the problems that persist in the use of currently available antidepressant medications and presents a list of attributes that would be characteristic of the ideal antidepressant.
AB - Although options for pharmacologic treatment for depression have grown seemingly exponentially over the past several decades, the current armamentarium of antidepressants continues to have limitations of both efficacy and tolerability. The problems include an unacceptable lack of efficacy, delayed onset of therapeutic effects, an inability to predict responses to one or another agent, drug-drug interactions, and difficulty with tolerability during both acute and chronic treatment. This article reviews the problems that persist in the use of currently available antidepressant medications and presents a list of attributes that would be characteristic of the ideal antidepressant.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033943902&partnerID=8YFLogxK
M3 - Article
C2 - 10910012
AN - SCOPUS:0033943902
VL - 61
SP - 5
EP - 15
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
SN - 0160-6689
IS - SUPPL. 10
ER -