Problems of Human Experimentation with New Drugs

Spencer Eth, W. Eugene Sanders, Joseph E. Johnson, J. G. Taggart

Research output: Contribution to journalLetterpeer-review


To the Editor: There are a number of disturbing features of “Adverse Reactions to Cephalothin and Cephapirin” (N Engl J Med 290:424–429, 1974). The authors report that their study was designed to evaluate the tolerance and pharmacokinetics of intravenously administered drugs in high dosage, “thereby mimicking treatment of infections such as bacterial endocarditis.” However, in the discussion they state, “In clinical practice the cephalosporins are prescribed in a variety of dosages and by a variety of routes; rapid intravenous infusion is perhaps least frequently employed, and it is even less often maintained for longer than one or two weeks.” Assuming. . .

Original languageEnglish (US)
Pages (from-to)1383
Number of pages1
JournalNew England Journal of Medicine
Issue number24
StatePublished - Jun 13 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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