Problems and solutions in the genetic analysis of late-onset Alzheimer's disease

John Hardy, Amanda Myers, Fabienne Wavrant-De Vrieze

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The identification of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease was a spectacularly successful application of genetic analysis to a complex trait, and it led to the hope and expectation that other risk loci for the disease would soon be forthcoming. Twelve years later, despite a huge amount of work, no other loci have been identified. In this article, we discuss the complexity of the problem and the pitfalls in the analytical methods that have been used and how we are approaching this problem.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalNeurodegenerative Diseases
Issue number4-5
StatePublished - 2004
Externally publishedYes


  • Alzheimer's disease
  • Amyloid protein precursor
  • Apolipoprotein E
  • Presenilin

ASJC Scopus subject areas

  • Clinical Neurology


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