Probiotics or pro-healers the role of beneficial bacteria in tissue repair

Jovanka Lukic, Vivien Chen, Ivana Strahinic, Jelena Begovic, Hadar Lev-Tov, Stephen C Davis, Marjana Tomic-Canic, Irena Pastar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Probiotics are beneficial microorganisms, known to exert numerous positive effects on human health, primarily in the battle against pathogens. Probiotics have been associated with improved healing of intestinal ulcers, and healing of infected cutaneous wounds. This article reviews the latest findings on probiotics related to their pro-healing properties on gut epithelium and skin. Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts, and epithelial cells' migration and function. Beneficial immunomodulatory effects of probiotics relate to modulation and activation of intraepithelial lymphocytes, natural killer cells, and macrophages through induced production of cytokines. Systemic effects of beneficial bacteria and link between gut microbiota, immune system, and cutaneous health through gut-brain-skin axes are discussed as well. In light of growing antibiotic resistance of pathogens, antibiotic use is becoming less effective in treating cutaneous and systemic infections. This review points to a new perspective and therapeutic potential of beneficial probiotic species as a safe alternative approach for treatment of patients affected by wound healing disorders and cutaneous infections.

Original languageEnglish (US)
JournalWound Repair and Regeneration
DOIs
StateAccepted/In press - Jan 1 2018

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Probiotics
Bacteria
Skin
Health
Lymphocyte Activation
Microbial Drug Resistance
Infection
Natural Killer Cells
Wound Healing
Ulcer
Cell Movement
Immune System
Epithelium
Fibroblasts
Epithelial Cells
Macrophages
Cytokines
Anti-Bacterial Agents
Wounds and Injuries
Brain

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

Probiotics or pro-healers the role of beneficial bacteria in tissue repair. / Lukic, Jovanka; Chen, Vivien; Strahinic, Ivana; Begovic, Jelena; Lev-Tov, Hadar; Davis, Stephen C; Tomic-Canic, Marjana; Pastar, Irena.

In: Wound Repair and Regeneration, 01.01.2018.

Research output: Contribution to journalArticle

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