TY - JOUR
T1 - Probiotics or pro-healers
T2 - the role of beneficial bacteria in tissue repair
AU - Lukic, Jovanka
AU - Chen, Vivien
AU - Strahinic, Ivana
AU - Begovic, Jelena
AU - Lev-Tov, Hadar
AU - Davis, Stephen C.
AU - Tomic-Canic, Marjana
AU - Pastar, Irena
N1 - Funding Information:
Source of Funding: Brian V. Jegasothy Foundation (IP), Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine, Ministry of Education, Science and Technological Development, Republic of Serbia; Grant No. ON173019 and National Institute of Health 1R01NR01564 (MTC).
Publisher Copyright:
© 2018 by the Wound Healing Society
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Probiotics are beneficial microorganisms, known to exert numerous positive effects on human health, primarily in the battle against pathogens. Probiotics have been associated with improved healing of intestinal ulcers, and healing of infected cutaneous wounds. This article reviews the latest findings on probiotics related to their pro-healing properties on gut epithelium and skin. Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts, and epithelial cells' migration and function. Beneficial immunomodulatory effects of probiotics relate to modulation and activation of intraepithelial lymphocytes, natural killer cells, and macrophages through induced production of cytokines. Systemic effects of beneficial bacteria and link between gut microbiota, immune system, and cutaneous health through gut–brain–skin axes are discussed as well. In light of growing antibiotic resistance of pathogens, antibiotic use is becoming less effective in treating cutaneous and systemic infections. This review points to a new perspective and therapeutic potential of beneficial probiotic species as a safe alternative approach for treatment of patients affected by wound healing disorders and cutaneous infections.
AB - Probiotics are beneficial microorganisms, known to exert numerous positive effects on human health, primarily in the battle against pathogens. Probiotics have been associated with improved healing of intestinal ulcers, and healing of infected cutaneous wounds. This article reviews the latest findings on probiotics related to their pro-healing properties on gut epithelium and skin. Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts, and epithelial cells' migration and function. Beneficial immunomodulatory effects of probiotics relate to modulation and activation of intraepithelial lymphocytes, natural killer cells, and macrophages through induced production of cytokines. Systemic effects of beneficial bacteria and link between gut microbiota, immune system, and cutaneous health through gut–brain–skin axes are discussed as well. In light of growing antibiotic resistance of pathogens, antibiotic use is becoming less effective in treating cutaneous and systemic infections. This review points to a new perspective and therapeutic potential of beneficial probiotic species as a safe alternative approach for treatment of patients affected by wound healing disorders and cutaneous infections.
UR - http://www.scopus.com/inward/record.url?scp=85041548045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041548045&partnerID=8YFLogxK
U2 - 10.1111/wrr.12607
DO - 10.1111/wrr.12607
M3 - Article
C2 - 29315980
AN - SCOPUS:85041548045
VL - 25
SP - 912
EP - 922
JO - Wound Repair and Regeneration
JF - Wound Repair and Regeneration
SN - 1067-1927
IS - 6
ER -