Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

Nichole Klatt, Lauren A. Canary, Xiaoyong Sun, Carol L. Vinton, Nicholas T. Funderburg, David R. Morcock, Mariam Quiñones, Clayton B. Deming, Molly Perkins, Daria J. Hazuda, Michael D. Miller, Michael M. Lederman, Julie A. Segre, Jeffrey D. Lifson, Elias K. Haddad, Jacob D. Estes, Jason M. Brenchley

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.

Original languageEnglish (US)
Pages (from-to)903-907
Number of pages5
JournalJournal of Clinical Investigation
Volume123
Issue number2
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

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Prebiotics
Probiotics
Macaca
Gastrointestinal Tract
Immunity
Synbiotics
Macaca nemestrina
HIV
Viremia
HIV Infections
Colon
Fibrosis
Morbidity
T-Lymphocytes
Mortality
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Klatt, N., Canary, L. A., Sun, X., Vinton, C. L., Funderburg, N. T., Morcock, D. R., ... Brenchley, J. M. (2013). Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. Journal of Clinical Investigation, 123(2), 903-907. https://doi.org/10.1172/JCI66227

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. / Klatt, Nichole; Canary, Lauren A.; Sun, Xiaoyong; Vinton, Carol L.; Funderburg, Nicholas T.; Morcock, David R.; Quiñones, Mariam; Deming, Clayton B.; Perkins, Molly; Hazuda, Daria J.; Miller, Michael D.; Lederman, Michael M.; Segre, Julie A.; Lifson, Jeffrey D.; Haddad, Elias K.; Estes, Jacob D.; Brenchley, Jason M.

In: Journal of Clinical Investigation, Vol. 123, No. 2, 01.02.2013, p. 903-907.

Research output: Contribution to journalArticle

Klatt, N, Canary, LA, Sun, X, Vinton, CL, Funderburg, NT, Morcock, DR, Quiñones, M, Deming, CB, Perkins, M, Hazuda, DJ, Miller, MD, Lederman, MM, Segre, JA, Lifson, JD, Haddad, EK, Estes, JD & Brenchley, JM 2013, 'Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques', Journal of Clinical Investigation, vol. 123, no. 2, pp. 903-907. https://doi.org/10.1172/JCI66227
Klatt, Nichole ; Canary, Lauren A. ; Sun, Xiaoyong ; Vinton, Carol L. ; Funderburg, Nicholas T. ; Morcock, David R. ; Quiñones, Mariam ; Deming, Clayton B. ; Perkins, Molly ; Hazuda, Daria J. ; Miller, Michael D. ; Lederman, Michael M. ; Segre, Julie A. ; Lifson, Jeffrey D. ; Haddad, Elias K. ; Estes, Jacob D. ; Brenchley, Jason M. / Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. In: Journal of Clinical Investigation. 2013 ; Vol. 123, No. 2. pp. 903-907.
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