Probing the mechanism of melamine-induced gold nanoparticle aggregation

Lu Yu, Thien Van Tran, Jiaqi Zou, Na Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Detection of melamine in the food has received much attention since several food safety incidents of melamine adulteration occurred in recent years. We previously developed a simple and rapid colorimetric method to detect melamine, which relies on melamine-induced aggregation of gold nanoparticles (GNPs). However, the mechanism behind this method is still not clear. Herein we systematically characterized the melamine-induced gold nanoparticle aggregates. Various experimental studies, including dynamic light scattering, zeta potential, UV-visible absorption spectroscopy and transmission electron microscopy (TEM), were carried out. The results have revealed that melamine is directly adsorbed to the GNP surface, thus decreasing the surface potential of GNPs in a concentration-dependent manner. Moreover, based on the understanding of the mechanism, we have been able to further improve our previously developed melamine detection method by introducing a critical coagulation concentration (CCC)-based salt titration step. This CCC-based salt titration not only significantly increases the detection sensitivity, but also enables a reliable quantification without any equipment.

Original languageEnglish (US)
Title of host publicationNANOMED 2012 - 6th IEEE International Conference on Nano/Molecular Medicine and Engineering
Pages21-26
Number of pages6
DOIs
StatePublished - Dec 1 2012
Event6th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2012 - Bangkok, Thailand
Duration: Nov 4 2012Nov 7 2012

Publication series

NameIEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
ISSN (Print)2159-6964
ISSN (Electronic)2159-6972

Other

Other6th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2012
CountryThailand
CityBangkok
Period11/4/1211/7/12

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Keywords

  • Aggregation kinetics
  • Colloid stability
  • Colorimetric sensing
  • Critical coagulation concentration
  • Gold nanoparticles
  • Melamine

ASJC Scopus subject areas

  • Molecular Medicine
  • Biomedical Engineering
  • Microbiology (medical)

Cite this

Yu, L., Van Tran, T., Zou, J., & Li, N. (2012). Probing the mechanism of melamine-induced gold nanoparticle aggregation. In NANOMED 2012 - 6th IEEE International Conference on Nano/Molecular Medicine and Engineering (pp. 21-26). [6509137] (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED). https://doi.org/10.1109/NANOMED.2012.6509137