Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

Erika L. Smith, Adrienne S. Brown, Edward Adjaye-Mensah, James N. Wilson

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A series of stilbazolium dimers were synthesized and investigated as sterically demanding ligands targeting the norepinephrine transporter (NET). The environmentally sensitive fluorescence of the dyes enables their use as self-reporting ligands; binding to and displacement from NET can be monitored by fluorescence microscopy.

Original languageEnglish (US)
Pages (from-to)1493-1496
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number8
DOIs
StatePublished - Feb 28 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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