Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

Erika L. Smith; Adrienne S. Brown; Edward Adjaye-Mensah; James N. Wilson

doi:10.1039/c2ob06796j

Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

Erika L. Smith, Adrienne S. Brown, Edward Adjaye-Mensah, James N. Wilson

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A series of stilbazolium dimers were synthesized and investigated as sterically demanding ligands targeting the norepinephrine transporter (NET). The environmentally sensitive fluorescence of the dyes enables their use as self-reporting ligands; binding to and displacement from NET can be monitored by fluorescence microscopy.

Original language	English (US)
Pages (from-to)	1493-1496
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	8
DOIs	https://doi.org/10.1039/c2ob06796j
State	Published - Feb 28 2012

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c2ob06796j

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abstract = "A series of stilbazolium dimers were synthesized and investigated as sterically demanding ligands targeting the norepinephrine transporter (NET). The environmentally sensitive fluorescence of the dyes enables their use as self-reporting ligands; binding to and displacement from NET can be monitored by fluorescence microscopy.",

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AU - Wilson, James N.

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Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

Abstract

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