Probing insulin sensitivity in diabetic kidney disease: is there a stronger role for functional imaging?

Michael L. Granda, Pooja Amarapurkar, Alessia Fornoni

Research output: Contribution to journalReview article

Abstract

Clinical and experimental evidence support a cause-effect relationship between altered insulin signaling and development of kidney disease of metabolic and non-metabolic origin. However, the current criteria to measure and/or estimate the insulin resistance (IR) are available as research tool but are very difficult to implement in the clinical practice. Therefore, a better understanding of the key players contributing to IR may lead to the development of new non-invasive tools to assess organ-specific insulin sensitivity (IS). We will therefore first introduce the concept that IR and kidney disease may be causally linked as suggested by clinical and experimental studies. We will then, expand on the potential mechanisms leading to altered renal insulin signaling. After reviewing the limitation of currently available strategies to determine IR, this review article will focus on imaging techniques that could be utilized to determine renal IR and that could be tested to predict kidney disease development and progression.

Original languageEnglish (US)
Pages (from-to)1085-1095
Number of pages11
JournalClinical science (London, England : 1979)
Volume132
Issue number11
DOIs
StatePublished - Jun 14 2018

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Diabetic Nephropathies
Insulin Resistance
Kidney Diseases
Insulin
Kidney
Disease Progression
Research

Keywords

  • diabetic nephropathy
  • diagnostics
  • functional imaging
  • imaging techniques
  • insulin resistance
  • insulin signalling

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Probing insulin sensitivity in diabetic kidney disease : is there a stronger role for functional imaging? / Granda, Michael L.; Amarapurkar, Pooja; Fornoni, Alessia.

In: Clinical science (London, England : 1979), Vol. 132, No. 11, 14.06.2018, p. 1085-1095.

Research output: Contribution to journalReview article

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