Proactive Semantic Interference is Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders: A Preliminary Study

David Loewenstein, Maria T. Greig, Rosie Curiel Cid, Rosemarie Rodriguez, Meredith Wicklund, Warren W. Barker, Jacqueline Hidalgo, Marian Rosado, Ranjan Duara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To evaluate the relationship between susceptibility to proactive semantic interference (PSI) and retroactive semantic interference (RSI) and brain amyloid load in non-demented elders. Methods: 27 participants (11 cognitively normal [CN] with subjective memory complaints, 8 CN without memory complaints, and 8 with mild cognitive impairment [MCI]) underwent complete neurological and neuropsychological evaluations. Participants also received the Semantic Interference Test (SIT) and AV-45 amyloid PET imaging. Results: High levels of association were present between total amyloid load, regional amyloid levels, and the PSI measure (in the entire sample and a subsample excluding MCI subjects). RSI and other memory measures showed much weaker associations or no associations with total and regional amyloid load. No associations between amyloid levels and non-memory performance were observed. Conclusions: In non-demented individuals, vulnerability to PSI was highly associated with total and regional beta-amyloid load and may be an early cognitive marker of brain pathology.

Original languageEnglish (US)
Pages (from-to)1276-1279
Number of pages4
JournalAmerican Journal of Geriatric Psychiatry
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2015

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Independent Living
Semantics
Amyloid
Brain
Pathology

Keywords

  • Amyloid
  • MCI
  • proactive interference
  • semantic interference

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

Proactive Semantic Interference is Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders : A Preliminary Study. / Loewenstein, David; Greig, Maria T.; Curiel Cid, Rosie; Rodriguez, Rosemarie; Wicklund, Meredith; Barker, Warren W.; Hidalgo, Jacqueline; Rosado, Marian; Duara, Ranjan.

In: American Journal of Geriatric Psychiatry, Vol. 23, No. 12, 01.12.2015, p. 1276-1279.

Research output: Contribution to journalArticle

Loewenstein, David ; Greig, Maria T. ; Curiel Cid, Rosie ; Rodriguez, Rosemarie ; Wicklund, Meredith ; Barker, Warren W. ; Hidalgo, Jacqueline ; Rosado, Marian ; Duara, Ranjan. / Proactive Semantic Interference is Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders : A Preliminary Study. In: American Journal of Geriatric Psychiatry. 2015 ; Vol. 23, No. 12. pp. 1276-1279.
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