Prior history of non-melanoma skin cancer is associated with increased mortality in patients with chronic lymphocytic leukemia

Jorge R. Toro, Patrick W. Blake, Magnus Björkholm, Sigurdur Y. Kristinsson, Zhuoqiao Wang, Ola Landgren

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

We investigated whether a previous diagnosis of non-melanoma skin cancer among chronic lymphocytic leukemia patients is a predictor of poor outcome. Using the Swedish Cancer Registry, we conducted a population-based study to evaluate the survival patterns among chronic lymphocytic leukemia patients with and without non-melanoma skin cancer. Cox proportional hazards regression models were used and Kaplan-Meier curves were constructed. Of a total of 12,041 chronic lymphocytic leukemia cases identified, 236 cases, including 111 squamous cell cancer, had a prior history of non-melanoma skin cancer. Chronic lymphocytic leukemia patients with a prior history of non-melanoma skin cancer had a 1.29-fold (95% CI 1.10-1.52; p=0.0024) increased risk of dying; and those with a history of squamous cell cancer had a further elevated 1.86-fold (95% CI 1.46-2.36; p<0.0001) risk of dying. Kaplan-Meier plots showed that patients with a history of non-melanoma skin cancer, particularly those with squamous cell cancer, had significantly poorer survival than chronic lymphocytic leukemia patients without nonmelanoma skin cancer (p<0.0001; log-rank test). Nonmelanoma skin cancer may be a novel clinical predictor of worse chronic lymphocytic leukemia outcome.

Original languageEnglish (US)
Pages (from-to)1460-1464
Number of pages5
JournalHaematologica
Volume94
Issue number10
DOIs
StatePublished - Oct 2009
Externally publishedYes

Keywords

  • Chronic lymphocytic leukemia
  • Immune disruption
  • Immunosuppression
  • Non-melanoma skin cancer
  • Pathogenesis
  • Prognosis
  • Squamous cell carcinoma
  • Survival
  • Susceptibility

ASJC Scopus subject areas

  • Hematology

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