Principals of neovascularization for tissue engineering

Masashi Nomi, Anthony Atala, Paolo De Coppi, Shay Soker

Research output: Contribution to journalReview articlepeer-review

334 Scopus citations


The goals in tissue engineering include the replacement of damaged, injured or missing body tissues with biological compatible substitutes such as bioengineered tissues. However, due to an initial mass loss after implantation, improved vascularization of the regenerated tissue is essential. Recent advances in understanding the process of blood vessel growth has offered significant tools for therapeutic neovascularization. Several angiogenic growth factors including vascular endothelial cell growth factor (VEGF) and basic fibroblast growth factor (bFGF) were used for vascularization of ischemic tissues. Three approaches have been used for vascularization of bioengineered tissue: incorporation of angiogenic factors in the bioengineered tissue, seeding endothelial cells with other cell types and prevascularization of matrices prior to cell seeding. This paper reviews the process of blood vessel growth and tissue vascularization, and discuss strategies for efficient vascularization of engineered tissues.

Original languageEnglish (US)
Pages (from-to)463-483
Number of pages21
JournalMolecular Aspects of Medicine
Issue number6
StatePublished - Dec 2002


  • Angiogenesis
  • bFGF
  • Endothelial cells
  • Gene therapy
  • VEGF

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine


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