Priming for improved hand strength in persons with chronic tetraplegia: A comparison of priming-augmented functional task practice, priming alone, and conventional exercise training

Joyce Gomes-Osman, Jacqueline A. Tibbett, Brandon P. Poe, Edelle C. Field-Fote

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Many everyday tasks cannot be accomplished without adequate grip strength, and corticomotor drive to the spinal motoneurons is a key determinant of grip strength. In persons with tetraplegia, damage to spinal pathways limits transmission of signals from motor cortex to spinal motoneurons. Corticomotor priming, which increases descending drive, should increase corticospinal transmission through the remaining spinal pathways resulting in increased grip strength. Since the motor and somatosensory cortices share reciprocal connections, corticomotor priming may also have potential to influence somatosensory function. The purpose of this study was to assess changes in grip (precision, power) force and tactile sensation associated with two different corticomotor priming approaches and a conventional training approach and to determine whether baseline values can predict responsiveness to training. Participants with chronic (=1 year) tetraplegia (n = 49) were randomized to one of two corticomotor priming approaches: functional task practice plus peripheral nerve somatosensory stimulation (FTP + PNSS) or PNSS alone, or to conventional exercise training (CET). To assess whether baseline corticospinal excitability (CSE) is predictive of responsiveness to training, in a subset of participants, we assessed pre-intervention CSE of the thenar muscles. Participants were trained 2 h daily, 5 days/week for 4 weeks. Thirty-seven participants completed the study. Following intervention, significant improvements in precision grip force were observed in both the stronger and weaker hand in the FTP + PNSS group (effect size: 0.51, p = 0.04 and 0.54, p = 0.03, respectively), and significant improvements in weak hand precision grip force were associated with both PNSS and CET (effect size: 0.54, p = 0.03 and 0.75, p = 0.02, respectively). No significant changes were observed in power grip force or somatosensory scores in any group. Across all groups, responsiveness to training as measured by change in weak hand power grip force was correlated with baseline force. Change in precision grip strength was correlated with measures of baseline CSE. These findings indicate that corticomotor priming with FTP + PNSS had the greatest influence on precision grip strength in both the stronger and weaker hand; however, both PNSS and CET were associated with improved precision grip strength in the weaker hand. Responsiveness to training may be associated with baseline CSE.

Original languageEnglish (US)
Article number242
JournalFrontiers in Neurology
Volume7
Issue numberJAN
DOIs
StatePublished - Jan 17 2017

Fingerprint

Quadriplegia
Hand Strength
Exercise
Hand
Motor Cortex
Motor Neurons
Somatosensory Cortex
Touch
Peripheral Nerves

Keywords

  • Activities of daily living
  • Hand function
  • Human movement system
  • Rehabilitation
  • Spinal cord injury

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Priming for improved hand strength in persons with chronic tetraplegia : A comparison of priming-augmented functional task practice, priming alone, and conventional exercise training. / Gomes-Osman, Joyce; Tibbett, Jacqueline A.; Poe, Brandon P.; Field-Fote, Edelle C.

In: Frontiers in Neurology, Vol. 7, No. JAN, 242, 17.01.2017.

Research output: Contribution to journalArticle

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