Primary structure of the canine CD4 antigen

Kerstin F. Milde, Gregory E. Conner, Daniel H. Mintz, Rodolfo Alejandro

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


After PCR amplification two overlapping cDNA clones encoding the dog homologue of the human CD4 glycoprotein were identified. This internal fragment of the mature protein including the complete extracellular domains, consists of 1297 bp with a deduced amino acid sequence of 432 residues. The dog CD4 molecule differs from the corresponding protein of other species including human in the second domain. We found nine extra residues in the beginning of that domain, a cysteine at position 138, usually involved in a disulfide bridge, is substituted by tryptophan, and three new glycosylation sites are present.

Original languageEnglish (US)
Pages (from-to)315-318
Number of pages4
JournalBBA - Gene Structure and Expression
Issue number3
StatePublished - Mar 20 1993


  • (Dog thymus)
  • cDNA cloning
  • Ig superfamily
  • Polymerase chain reaction
  • RNA
  • Sequence homology

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Genetics
  • Structural Biology


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