Primary seminal vesicle adenocarcinoma: A lethal yet cryptic malignancy with review of literature

Abhishek Bhat, Indraneel Banerjee, Oleksandr N. Kryvenko, Ramgopal Satyanarayana

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The rarity of primary seminal vesical adenocarcinoma (PSVA) coupled with mostly late and advanced presentation with high mortality makes it an unanticipated malignancy with poor prognosis. Although there has been sporadic reporting of cases, the dearth of literature makes standardised care a challenge. The detection has incorporated immunohistochemistry for establishing the site of origin as well as the differentiation of primary from metastatic cancer. Surgical management with seminal vesiculectomy continues to be the mainstay of treatment, but difficult anatomy and delayed intervention do lead to an increased chance of residual disease that may warrant further adjuvant chemoradiation. We present a case report where PSVA developed in a patient with Zinner syndrome - an observation that is extremely rare with a literature review of PSVA including the various aspects of management including contemporary diagnosis techniques.

Original languageEnglish (US)
Article numbere232994
JournalBMJ case reports
Issue number12
StatePublished - Dec 17 2019


  • urinary and genital tract disorders
  • urological cancer
  • urological surgery

ASJC Scopus subject areas

  • Medicine(all)


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