Primary pulmonary sarcoma: A clinicopathologic study of 26 cases

Suzanne B. Keel, Emile Bacha, Eugene J. Mark, G. Petur Nielsen, Andrew Rosenberg

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

The clinical and pathologic features of 26 primary pulmonary sarcomas were analyzed. Fourteen patients were male and 12 were female; ranging in age from 18 to 75 years (mean, 48 yr). The tumors measured from 0.9 cm in greatest diameter to filling the entire hemithorax. Thirteen tumors were in the left lung and nine in the right lung; one was bilateral, two were in the pulmonary artery, and the location of one tumor was not available. The histologic diagnoses were malignant fibrous histiocytoma (7), synovial sarcoma (6), malignant peripheral nerve sheath tumor (3), leiomyosarcoma (3), angiosarcoma (2), intimal sarcoma (2), fibrosarcoma (2), and one case of epithelioid hemangioendothelioma. Immunohistochemical and ultrastructural examination supported these diagnoses. Morphologically, the differential diagnosis often included sarcomatoid carcinoma or desmoplastic malignant mesothelioma. Patients were treated with surgery, chemotherapy, radiation therapy, or a combination of these. Follow-up was available for 22 patients and ranged from 2 to 183 months (mean, 45 mo). Fourteen patients are free of disease, four died of disease, three are alive with disease, and one died of surgical complications. A variety of sarcomas, especially malignant fibrous histiocytoma and synovial sarcoma, arise within the pulmonary parenchyma. These tumors have the potential to behave aggressively but can be cured by resection, with or without adjuvant therapy. Immunohistochemistry and electron microscopy can be helpful in distinguishing primary pulmonary sarcoma from other tumors in the differential diagnosis.

Original languageEnglish
Pages (from-to)1124-1131
Number of pages8
JournalModern Pathology
Volume12
Issue number12
StatePublished - Dec 1 1999
Externally publishedYes

Fingerprint

Sarcoma
Lung
Synovial Sarcoma
Malignant Fibrous Histiocytoma
Neoplasms
Differential Diagnosis
Epithelioid Hemangioendothelioma
Tunica Intima
Hemangiosarcoma
Leiomyosarcoma
Fibrosarcoma
Neurilemmoma
Pulmonary Artery
Electron Microscopy
Radiotherapy
Immunohistochemistry
Carcinoma
Drug Therapy
Therapeutics

Keywords

  • Lung
  • Malignancy
  • Pulmonary
  • Sarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Keel, S. B., Bacha, E., Mark, E. J., Nielsen, G. P., & Rosenberg, A. (1999). Primary pulmonary sarcoma: A clinicopathologic study of 26 cases. Modern Pathology, 12(12), 1124-1131.

Primary pulmonary sarcoma : A clinicopathologic study of 26 cases. / Keel, Suzanne B.; Bacha, Emile; Mark, Eugene J.; Nielsen, G. Petur; Rosenberg, Andrew.

In: Modern Pathology, Vol. 12, No. 12, 01.12.1999, p. 1124-1131.

Research output: Contribution to journalArticle

Keel, SB, Bacha, E, Mark, EJ, Nielsen, GP & Rosenberg, A 1999, 'Primary pulmonary sarcoma: A clinicopathologic study of 26 cases', Modern Pathology, vol. 12, no. 12, pp. 1124-1131.
Keel SB, Bacha E, Mark EJ, Nielsen GP, Rosenberg A. Primary pulmonary sarcoma: A clinicopathologic study of 26 cases. Modern Pathology. 1999 Dec 1;12(12):1124-1131.
Keel, Suzanne B. ; Bacha, Emile ; Mark, Eugene J. ; Nielsen, G. Petur ; Rosenberg, Andrew. / Primary pulmonary sarcoma : A clinicopathologic study of 26 cases. In: Modern Pathology. 1999 ; Vol. 12, No. 12. pp. 1124-1131.
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