Primary pediatric cardiac malignancies

The SEER experience

James S. Davis, Bassan J. Allan, Eduardo Perez, Holly Neville, Juan E Sola

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose Pediatric cardiac malignancies are exceedingly rare. We sought to examine demographics, presentation, and outcomes for this pathology. Methods The SEER registry from 1973 to 2008 was queried for all patients \20 years of age with cardiac malignancies. Results A total of 25 pediatric patients were identified with primary cardiac malignancies, with age-adjusted incidence of 0.00686 per 100,000 United States population. Median age at diagnosis was 10 years. The majority of patients were adolescent (n = 13, 52 %), Caucasian (n = 17, 68 %) and males (n = 14, 56 %). The most common histology was soft tissue sarcoma (n = 10, 40%), followed by non-Hodgkin lymphoma and teratoma (both n = 3, 12 %). Six patients presented with distant disease. More than half of patients (n = 16, 64 %) underwent surgical resection, while four patients (16 %) underwent radiation. The mean survival time for the cohort was 47 ± 67 months, with 14 (56 %) patients dying over the study period. Lymphomas had significantly longer survival than other malignancies (108 ± 66 vs. 36 ± 66, p = 0.03), while lack of surgical treatment was associated with worse survival (p = 0.016). Conclusions Primary malignant cardiac tumors are exceedingly rare in pediatric patients. They are most commonly soft tissue sarcomas and lymphomas demonstrated longer survival.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalPediatric Surgery International
Volume29
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

Pediatrics
Neoplasms
Sarcoma
Survival
Lymphoma
Heart Neoplasms
Teratoma
Non-Hodgkin's Lymphoma
Registries
Histology
Survival Rate
Demography
Radiation
Pathology
Incidence
Population

Keywords

  • Cardiology
  • Outcomes research
  • Pediatric hematology/oncology
  • Rare tumors
  • SEER

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Primary pediatric cardiac malignancies : The SEER experience. / Davis, James S.; Allan, Bassan J.; Perez, Eduardo; Neville, Holly; Sola, Juan E.

In: Pediatric Surgery International, Vol. 29, No. 5, 01.05.2013, p. 425-429.

Research output: Contribution to journalArticle

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abstract = "Purpose Pediatric cardiac malignancies are exceedingly rare. We sought to examine demographics, presentation, and outcomes for this pathology. Methods The SEER registry from 1973 to 2008 was queried for all patients \20 years of age with cardiac malignancies. Results A total of 25 pediatric patients were identified with primary cardiac malignancies, with age-adjusted incidence of 0.00686 per 100,000 United States population. Median age at diagnosis was 10 years. The majority of patients were adolescent (n = 13, 52 {\%}), Caucasian (n = 17, 68 {\%}) and males (n = 14, 56 {\%}). The most common histology was soft tissue sarcoma (n = 10, 40{\%}), followed by non-Hodgkin lymphoma and teratoma (both n = 3, 12 {\%}). Six patients presented with distant disease. More than half of patients (n = 16, 64 {\%}) underwent surgical resection, while four patients (16 {\%}) underwent radiation. The mean survival time for the cohort was 47 ± 67 months, with 14 (56 {\%}) patients dying over the study period. Lymphomas had significantly longer survival than other malignancies (108 ± 66 vs. 36 ± 66, p = 0.03), while lack of surgical treatment was associated with worse survival (p = 0.016). Conclusions Primary malignant cardiac tumors are exceedingly rare in pediatric patients. They are most commonly soft tissue sarcomas and lymphomas demonstrated longer survival.",
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N2 - Purpose Pediatric cardiac malignancies are exceedingly rare. We sought to examine demographics, presentation, and outcomes for this pathology. Methods The SEER registry from 1973 to 2008 was queried for all patients \20 years of age with cardiac malignancies. Results A total of 25 pediatric patients were identified with primary cardiac malignancies, with age-adjusted incidence of 0.00686 per 100,000 United States population. Median age at diagnosis was 10 years. The majority of patients were adolescent (n = 13, 52 %), Caucasian (n = 17, 68 %) and males (n = 14, 56 %). The most common histology was soft tissue sarcoma (n = 10, 40%), followed by non-Hodgkin lymphoma and teratoma (both n = 3, 12 %). Six patients presented with distant disease. More than half of patients (n = 16, 64 %) underwent surgical resection, while four patients (16 %) underwent radiation. The mean survival time for the cohort was 47 ± 67 months, with 14 (56 %) patients dying over the study period. Lymphomas had significantly longer survival than other malignancies (108 ± 66 vs. 36 ± 66, p = 0.03), while lack of surgical treatment was associated with worse survival (p = 0.016). Conclusions Primary malignant cardiac tumors are exceedingly rare in pediatric patients. They are most commonly soft tissue sarcomas and lymphomas demonstrated longer survival.

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