Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT)

Single institution experience in a large cohort of patients

Soley Bayraktar, Ulas D. Bayraktar, Alexandra Stefanovic, Izidore Lossos

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Extranodal marginal zone B-cell lymphoma is the most common orbital tumour. We conducted a retrospective analysis to examine: (i) the impact of initial presentation and staging on outcome and (ii) response to various treatment modalities and the effect of the latter on recurrence. Ninety patients with primary ocular adnexal marginal zone lymphoma (POAML) diagnosed at our institution between 1984 and 2009 were studied. POAML was associated with monoclonal gammopathy (13%) at presentation. Most POAML patients (86%) presented with Ann-Arbor stage I disease. Radiotherapy led to excellent local control, but relapses occurred in 18% of Ann-Arbor stage I patients during a median follow-up of 5 years. Local relapses, including secondary central nervous system (CNS) involvement, were observed in patients receiving radiation doses <30·6 Gy. No differences in relapse rate and survival were observed between patients who did or did not undergo staging bone marrow biopsy. Ann-Arbor stage II-IV disease and high lactate dehydrogenase levels were associated with shorter freedom from progression. In conclusion, POAML is an indolent lymphoma with continuous risk for relapse. Radiation doses of at least 30·6 Gy should be given in Ann-Arbor stage I disease, since lower doses may be more frequently associated with relapses, including CNS relapses.

Original languageEnglish
Pages (from-to)72-80
Number of pages9
JournalBritish Journal of Haematology
Volume152
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Marginal Zone B-Cell Lymphoma
Recurrence
Lymphoma
Central Nervous System
Radiation
Paraproteinemias
L-Lactate Dehydrogenase
Radiotherapy
Survival Rate
Bone Marrow
Biopsy

Keywords

  • Bone marrow biopsy
  • Chemotherapy
  • Monoclonal gammopathy
  • Primary ocular adnexal marginal zone lymphoma
  • Radiotherapy

ASJC Scopus subject areas

  • Hematology

Cite this

Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT) : Single institution experience in a large cohort of patients. / Bayraktar, Soley; Bayraktar, Ulas D.; Stefanovic, Alexandra; Lossos, Izidore.

In: British Journal of Haematology, Vol. 152, No. 1, 01.01.2011, p. 72-80.

Research output: Contribution to journalArticle

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