Abstract
Extranodal marginal zone B-cell lymphoma is the most common orbital tumour. We conducted a retrospective analysis to examine: (i) the impact of initial presentation and staging on outcome and (ii) response to various treatment modalities and the effect of the latter on recurrence. Ninety patients with primary ocular adnexal marginal zone lymphoma (POAML) diagnosed at our institution between 1984 and 2009 were studied. POAML was associated with monoclonal gammopathy (13%) at presentation. Most POAML patients (86%) presented with Ann-Arbor stage I disease. Radiotherapy led to excellent local control, but relapses occurred in 18% of Ann-Arbor stage I patients during a median follow-up of 5 years. Local relapses, including secondary central nervous system (CNS) involvement, were observed in patients receiving radiation doses <30·6 Gy. No differences in relapse rate and survival were observed between patients who did or did not undergo staging bone marrow biopsy. Ann-Arbor stage II-IV disease and high lactate dehydrogenase levels were associated with shorter freedom from progression. In conclusion, POAML is an indolent lymphoma with continuous risk for relapse. Radiation doses of at least 30·6 Gy should be given in Ann-Arbor stage I disease, since lower doses may be more frequently associated with relapses, including CNS relapses.
| Original language | English |
|---|---|
| Pages (from-to) | 72-80 |
| Number of pages | 9 |
| Journal | British Journal of Haematology |
| Volume | 152 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2011 |
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Keywords
- Bone marrow biopsy
- Chemotherapy
- Monoclonal gammopathy
- Primary ocular adnexal marginal zone lymphoma
- Radiotherapy
ASJC Scopus subject areas
- Hematology
Cite this
Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT) : Single institution experience in a large cohort of patients. / Bayraktar, Soley; Bayraktar, Ulas D.; Stefanovic, Alexandra; Lossos, Izidore.
In: British Journal of Haematology, Vol. 152, No. 1, 01.01.2011, p. 72-80.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT)
T2 - Single institution experience in a large cohort of patients
AU - Bayraktar, Soley
AU - Bayraktar, Ulas D.
AU - Stefanovic, Alexandra
AU - Lossos, Izidore
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Extranodal marginal zone B-cell lymphoma is the most common orbital tumour. We conducted a retrospective analysis to examine: (i) the impact of initial presentation and staging on outcome and (ii) response to various treatment modalities and the effect of the latter on recurrence. Ninety patients with primary ocular adnexal marginal zone lymphoma (POAML) diagnosed at our institution between 1984 and 2009 were studied. POAML was associated with monoclonal gammopathy (13%) at presentation. Most POAML patients (86%) presented with Ann-Arbor stage I disease. Radiotherapy led to excellent local control, but relapses occurred in 18% of Ann-Arbor stage I patients during a median follow-up of 5 years. Local relapses, including secondary central nervous system (CNS) involvement, were observed in patients receiving radiation doses <30·6 Gy. No differences in relapse rate and survival were observed between patients who did or did not undergo staging bone marrow biopsy. Ann-Arbor stage II-IV disease and high lactate dehydrogenase levels were associated with shorter freedom from progression. In conclusion, POAML is an indolent lymphoma with continuous risk for relapse. Radiation doses of at least 30·6 Gy should be given in Ann-Arbor stage I disease, since lower doses may be more frequently associated with relapses, including CNS relapses.
AB - Extranodal marginal zone B-cell lymphoma is the most common orbital tumour. We conducted a retrospective analysis to examine: (i) the impact of initial presentation and staging on outcome and (ii) response to various treatment modalities and the effect of the latter on recurrence. Ninety patients with primary ocular adnexal marginal zone lymphoma (POAML) diagnosed at our institution between 1984 and 2009 were studied. POAML was associated with monoclonal gammopathy (13%) at presentation. Most POAML patients (86%) presented with Ann-Arbor stage I disease. Radiotherapy led to excellent local control, but relapses occurred in 18% of Ann-Arbor stage I patients during a median follow-up of 5 years. Local relapses, including secondary central nervous system (CNS) involvement, were observed in patients receiving radiation doses <30·6 Gy. No differences in relapse rate and survival were observed between patients who did or did not undergo staging bone marrow biopsy. Ann-Arbor stage II-IV disease and high lactate dehydrogenase levels were associated with shorter freedom from progression. In conclusion, POAML is an indolent lymphoma with continuous risk for relapse. Radiation doses of at least 30·6 Gy should be given in Ann-Arbor stage I disease, since lower doses may be more frequently associated with relapses, including CNS relapses.
KW - Bone marrow biopsy
KW - Chemotherapy
KW - Monoclonal gammopathy
KW - Primary ocular adnexal marginal zone lymphoma
KW - Radiotherapy
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U2 - 10.1111/j.1365-2141.2010.08429.x
DO - 10.1111/j.1365-2141.2010.08429.x
M3 - Article
VL - 152
SP - 72
EP - 80
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -