TY - JOUR
T1 - Primary melanocytic lesions of the rabbit choroid following topical application of 7, 12-dimethmbenz[a] anthracene
T2 - Preliminary observations
AU - Folberg, Robert
AU - Baron, Jeffrey
AU - Reeves, Raymond D.
AU - Stevens, Reggie H.
AU - Tse, David T.
N1 - Funding Information:
This study was supported in part by Public Health Service grant EY-07043 (Dr.
Funding Information:
Folberg), by the Center for Electron Microscopy Research, University of Iowa, and in part by an unrestricted grant from Research to Prevent Blindness, Inc., New York. Dr. Folberg is a Research to Prevent Blindness Senior Scientific Investigator.
PY - 1990
Y1 - 1990
N2 - There are no available animal models of primary human uveal melanoma, a potentially blinding and lethal condition. In an attempt to develop such a model, 7,12-dimethylbenz[a]anthracene in acetone was applied topically to the sclera of Dutch (pigmented) rabbits. Melanocytic hyperplasia was identified histologically in the choroid of 9 of 18 rabbits within 19 weeks following 5-14 weekly topical applications of a 1% solution of 7,12-dimethylbenz[a]anthracene in acetone (10 μ1 per application). The clinical emergence of fundus pigmentation was documented photographically in six of these nine rabbit eyes. This study is, to the best of our knowledge, the first demonstration of a uveal melanocytic response to a chemical carcinogen in an animal eye large enough to be examined clinically.
AB - There are no available animal models of primary human uveal melanoma, a potentially blinding and lethal condition. In an attempt to develop such a model, 7,12-dimethylbenz[a]anthracene in acetone was applied topically to the sclera of Dutch (pigmented) rabbits. Melanocytic hyperplasia was identified histologically in the choroid of 9 of 18 rabbits within 19 weeks following 5-14 weekly topical applications of a 1% solution of 7,12-dimethylbenz[a]anthracene in acetone (10 μ1 per application). The clinical emergence of fundus pigmentation was documented photographically in six of these nine rabbit eyes. This study is, to the best of our knowledge, the first demonstration of a uveal melanocytic response to a chemical carcinogen in an animal eye large enough to be examined clinically.
UR - http://www.scopus.com/inward/record.url?scp=0025103668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025103668&partnerID=8YFLogxK
U2 - 10.3109/15569529009036317
DO - 10.3109/15569529009036317
M3 - Article
AN - SCOPUS:0025103668
VL - 9
SP - 109
EP - 129
JO - Journal of Toxicology - Cutaneous and Ocular Toxicology
JF - Journal of Toxicology - Cutaneous and Ocular Toxicology
SN - 1556-9527
IS - 2
ER -