Abstract
There are no available animal models of primary human uveal melanoma, a potentially blinding and lethal condition. In an attempt to develop such a model, 7,12-dimethylbenz[a]anthracene in acetone was applied topically to the sclera of Dutch (pigmented) rabbits. Melanocytic hyperplasia was identified histologically in the choroid of 9 of 18 rabbits within 19 weeks following 5-14 weekly topical applications of a 1% solution of 7,12-dimethylbenz[a]anthracene in acetone (10 μ1 per application). The clinical emergence of fundus pigmentation was documented photographically in six of these nine rabbit eyes. This study is, to the best of our knowledge, the first demonstration of a uveal melanocytic response to a chemical carcinogen in an animal eye large enough to be examined clinically.
| Original language | English |
|---|---|
| Pages (from-to) | 109-129 |
| Number of pages | 21 |
| Journal | Cutaneous and Ocular Toxicology |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1990 |
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ASJC Scopus subject areas
- Toxicology
- Ophthalmology
- Health, Toxicology and Mutagenesis
Cite this
Primary melanocytic lesions of the rabbit choroid following topical application of 7, 12-dimethmbenz[a] anthracene : Preliminary observations. / Folberg, Robert; Baron, Jeffrey; Reeves, Raymond D.; Stevens, Reggie H.; Tse, David.
In: Cutaneous and Ocular Toxicology, Vol. 9, No. 2, 01.01.1990, p. 109-129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary melanocytic lesions of the rabbit choroid following topical application of 7, 12-dimethmbenz[a] anthracene
T2 - Preliminary observations
AU - Folberg, Robert
AU - Baron, Jeffrey
AU - Reeves, Raymond D.
AU - Stevens, Reggie H.
AU - Tse, David
PY - 1990/1/1
Y1 - 1990/1/1
N2 - There are no available animal models of primary human uveal melanoma, a potentially blinding and lethal condition. In an attempt to develop such a model, 7,12-dimethylbenz[a]anthracene in acetone was applied topically to the sclera of Dutch (pigmented) rabbits. Melanocytic hyperplasia was identified histologically in the choroid of 9 of 18 rabbits within 19 weeks following 5-14 weekly topical applications of a 1% solution of 7,12-dimethylbenz[a]anthracene in acetone (10 μ1 per application). The clinical emergence of fundus pigmentation was documented photographically in six of these nine rabbit eyes. This study is, to the best of our knowledge, the first demonstration of a uveal melanocytic response to a chemical carcinogen in an animal eye large enough to be examined clinically.
AB - There are no available animal models of primary human uveal melanoma, a potentially blinding and lethal condition. In an attempt to develop such a model, 7,12-dimethylbenz[a]anthracene in acetone was applied topically to the sclera of Dutch (pigmented) rabbits. Melanocytic hyperplasia was identified histologically in the choroid of 9 of 18 rabbits within 19 weeks following 5-14 weekly topical applications of a 1% solution of 7,12-dimethylbenz[a]anthracene in acetone (10 μ1 per application). The clinical emergence of fundus pigmentation was documented photographically in six of these nine rabbit eyes. This study is, to the best of our knowledge, the first demonstration of a uveal melanocytic response to a chemical carcinogen in an animal eye large enough to be examined clinically.
UR - http://www.scopus.com/inward/record.url?scp=0025103668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025103668&partnerID=8YFLogxK
U2 - 10.3109/15569529009036317
DO - 10.3109/15569529009036317
M3 - Article
AN - SCOPUS:0025103668
VL - 9
SP - 109
EP - 129
JO - Cutaneous and Ocular Toxicology
JF - Cutaneous and Ocular Toxicology
SN - 1556-9527
IS - 2
ER -