Primary melanocytic lesions of the rabbit choroid following topical application of 7, 12-dimethmbenz[a] anthracene: Preliminary observations

Robert Folberg, Jeffrey Baron, Raymond D. Reeves, Reggie H. Stevens, David Tse

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

There are no available animal models of primary human uveal melanoma, a potentially blinding and lethal condition. In an attempt to develop such a model, 7,12-dimethylbenz[a]anthracene in acetone was applied topically to the sclera of Dutch (pigmented) rabbits. Melanocytic hyperplasia was identified histologically in the choroid of 9 of 18 rabbits within 19 weeks following 5-14 weekly topical applications of a 1% solution of 7,12-dimethylbenz[a]anthracene in acetone (10 μ1 per application). The clinical emergence of fundus pigmentation was documented photographically in six of these nine rabbit eyes. This study is, to the best of our knowledge, the first demonstration of a uveal melanocytic response to a chemical carcinogen in an animal eye large enough to be examined clinically.

Original languageEnglish
Pages (from-to)109-129
Number of pages21
JournalCutaneous and Ocular Toxicology
Volume9
Issue number2
DOIs
StatePublished - Jan 1 1990

Fingerprint

Choroid
Acetone
Animals
Rabbits
Carcinogens
Sclera
Demonstrations
Pigmentation
Hyperplasia
Animal Models
anthracene

ASJC Scopus subject areas

  • Toxicology
  • Ophthalmology
  • Health, Toxicology and Mutagenesis

Cite this

Primary melanocytic lesions of the rabbit choroid following topical application of 7, 12-dimethmbenz[a] anthracene : Preliminary observations. / Folberg, Robert; Baron, Jeffrey; Reeves, Raymond D.; Stevens, Reggie H.; Tse, David.

In: Cutaneous and Ocular Toxicology, Vol. 9, No. 2, 01.01.1990, p. 109-129.

Research output: Contribution to journalArticle

@article{a985f870374c4a7c8227bbbf82e5f743,
title = "Primary melanocytic lesions of the rabbit choroid following topical application of 7, 12-dimethmbenz[a] anthracene: Preliminary observations",
abstract = "There are no available animal models of primary human uveal melanoma, a potentially blinding and lethal condition. In an attempt to develop such a model, 7,12-dimethylbenz[a]anthracene in acetone was applied topically to the sclera of Dutch (pigmented) rabbits. Melanocytic hyperplasia was identified histologically in the choroid of 9 of 18 rabbits within 19 weeks following 5-14 weekly topical applications of a 1{\%} solution of 7,12-dimethylbenz[a]anthracene in acetone (10 μ1 per application). The clinical emergence of fundus pigmentation was documented photographically in six of these nine rabbit eyes. This study is, to the best of our knowledge, the first demonstration of a uveal melanocytic response to a chemical carcinogen in an animal eye large enough to be examined clinically.",
author = "Robert Folberg and Jeffrey Baron and Reeves, {Raymond D.} and Stevens, {Reggie H.} and David Tse",
year = "1990",
month = "1",
day = "1",
doi = "10.3109/15569529009036317",
language = "English",
volume = "9",
pages = "109--129",
journal = "Cutaneous and Ocular Toxicology",
issn = "1556-9527",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Primary melanocytic lesions of the rabbit choroid following topical application of 7, 12-dimethmbenz[a] anthracene

T2 - Preliminary observations

AU - Folberg, Robert

AU - Baron, Jeffrey

AU - Reeves, Raymond D.

AU - Stevens, Reggie H.

AU - Tse, David

PY - 1990/1/1

Y1 - 1990/1/1

N2 - There are no available animal models of primary human uveal melanoma, a potentially blinding and lethal condition. In an attempt to develop such a model, 7,12-dimethylbenz[a]anthracene in acetone was applied topically to the sclera of Dutch (pigmented) rabbits. Melanocytic hyperplasia was identified histologically in the choroid of 9 of 18 rabbits within 19 weeks following 5-14 weekly topical applications of a 1% solution of 7,12-dimethylbenz[a]anthracene in acetone (10 μ1 per application). The clinical emergence of fundus pigmentation was documented photographically in six of these nine rabbit eyes. This study is, to the best of our knowledge, the first demonstration of a uveal melanocytic response to a chemical carcinogen in an animal eye large enough to be examined clinically.

AB - There are no available animal models of primary human uveal melanoma, a potentially blinding and lethal condition. In an attempt to develop such a model, 7,12-dimethylbenz[a]anthracene in acetone was applied topically to the sclera of Dutch (pigmented) rabbits. Melanocytic hyperplasia was identified histologically in the choroid of 9 of 18 rabbits within 19 weeks following 5-14 weekly topical applications of a 1% solution of 7,12-dimethylbenz[a]anthracene in acetone (10 μ1 per application). The clinical emergence of fundus pigmentation was documented photographically in six of these nine rabbit eyes. This study is, to the best of our knowledge, the first demonstration of a uveal melanocytic response to a chemical carcinogen in an animal eye large enough to be examined clinically.

UR - http://www.scopus.com/inward/record.url?scp=0025103668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025103668&partnerID=8YFLogxK

U2 - 10.3109/15569529009036317

DO - 10.3109/15569529009036317

M3 - Article

AN - SCOPUS:0025103668

VL - 9

SP - 109

EP - 129

JO - Cutaneous and Ocular Toxicology

JF - Cutaneous and Ocular Toxicology

SN - 1556-9527

IS - 2

ER -