Primary mediastinal large B-Cell lymphoma with translocations involving BCL6 and MYC (Double-Hit Lymphoma)

Germán Campuzano-Zuluaga, Daniel Ortiz, Jing Hong Peng, Offiong Ikpatt, Yao-Shan Fan, Julio Barredo, Francisco Vega, Jennifer Chapman-Fredricks

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objectives: Primary mediastinal large B-cell lymphomas (PMLBCLs) are aggressive lymphomas with characteristic clinical, morphologic, and immunophenotypic features. "Double-hit" (DH) lymphomas are B-cell neoplasms characterized by a translocation involving MYC and either BCL2 or BCL6. In the indexed literature, there are no reported cases of PMLBCL associated with DH or triple-hit events. Methods: Herein, we present a case of a 15-year-old girl with PMLBCL who had typical clinical, morphologic, and immunophenotypic features. Results: Fluorescent in situ hybridization studies showed rearrangements involving MYC and BCL6. We also excluded the possibility of a reciprocal t(3;8) (3q27;8q24) BCL6/MYC translocation. Conclusions: This case expands the current spectrum of lymphomas subtypes in which DH can be found and supports the rationale for cytogenetic testing for DH abnormalities in all cases of aggressive large B-cell lymphomas regardless of subtype.

Original languageEnglish (US)
Pages (from-to)710-716
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume145
Issue number5
DOIs
StatePublished - May 1 2016

Keywords

  • BCL6
  • Double hit
  • Large B-cell lymphoma
  • MYC
  • Primary mediastinal large B-cell lymphoma

ASJC Scopus subject areas

  • Medicine(all)

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