Primary malignant melanoma of the vagina: A clinicopathological analysis of 10 cases

Gholamreza Borazjani, Konald A. Prem, Takashi Okagaki, Leo B. Twiggs, Leon L. Adcock

Research output: Contribution to journalArticle

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Abstract

We retrospectively analyzed clinicopathological findings in 10 cases of primary malignant melanoma of the vagina. The main presenting symptoms were vaginal bleeding, vaginal discharge, and feeling of a mass. The tumors were predominantly located in the lowest one-third and in the anterolateral aspect of the vagina. Patients underwent various surgical procedures, radiation therapy, and chemotherapeutic modalities. The mean survival time and the recurrence time from the time of diagnosis were 15 and 8 months, respectively. The tumors were examined for histological characteristics of cell type, presence of melanin pigment, depth of invasion, vascular invasion, intraepithelial spread, junctional activity, and mitotic count. Of all these histological variables, the mean survival time had a significant correlation to mitotic count (P < 0.04). We concluded that patients with lower mitotic counts (less than 6 per 10 HPF) had better survival (21 months) compared to patients with mitotic counts greater than 6 per 10 HPF who had a mean survival of only 7 months.

Original languageEnglish
Pages (from-to)264-267
Number of pages4
JournalGynecologic Oncology
Volume37
Issue number2
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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Vagina
Melanoma
Survival Rate
Vaginal Discharge
Survival
Uterine Hemorrhage
Melanins
Blood Vessels
Neoplasms
Emotions
Radiotherapy
Recurrence

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Borazjani, G., Prem, K. A., Okagaki, T., Twiggs, L. B., & Adcock, L. L. (1990). Primary malignant melanoma of the vagina: A clinicopathological analysis of 10 cases. Gynecologic Oncology, 37(2), 264-267. https://doi.org/10.1016/0090-8258(90)90345-L

Primary malignant melanoma of the vagina : A clinicopathological analysis of 10 cases. / Borazjani, Gholamreza; Prem, Konald A.; Okagaki, Takashi; Twiggs, Leo B.; Adcock, Leon L.

In: Gynecologic Oncology, Vol. 37, No. 2, 01.01.1990, p. 264-267.

Research output: Contribution to journalArticle

Borazjani, G, Prem, KA, Okagaki, T, Twiggs, LB & Adcock, LL 1990, 'Primary malignant melanoma of the vagina: A clinicopathological analysis of 10 cases', Gynecologic Oncology, vol. 37, no. 2, pp. 264-267. https://doi.org/10.1016/0090-8258(90)90345-L
Borazjani, Gholamreza ; Prem, Konald A. ; Okagaki, Takashi ; Twiggs, Leo B. ; Adcock, Leon L. / Primary malignant melanoma of the vagina : A clinicopathological analysis of 10 cases. In: Gynecologic Oncology. 1990 ; Vol. 37, No. 2. pp. 264-267.
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