Primary malignant fibrous histiocytoma of bone: Report of six cases with ultrastructural study and analysis of the literature

L. Ghandur-Mnaymneh, Gregory A Zych, W. Mnaymneh

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Six cases of malignant fibrous histiocytoma (MFH) primary in bone were studied clinicopathologically with ultrastructural study of three. The histologic differentiation of MFH from osteosarcoma and from fibrosarcoma is discussed. Two of the six cases had highly malignant tumors histologically designated as Grade III and IV; one died with diffuse metastatic disease eight months after diagnosis and the second developed pulmonary metastases within ten months. Review of the literature revealed that 45 of the total 119 reported cases had been followed for less than five years; these cases were considered unevaluable for assessing biologic behavior. The remaining 74 cases, followed for more than five years or until death, showed a 36.5% five-year survival rate. All but one of the cases which developed metastasis within five years did so within the first two years. It is therefore concluded that MFH of bone is a rapidly metastasizing tumor with a relatively low five-year survival rate. Paradoxically, 13 of these 74 cases (17.6%) survived between five and 38 years with no evidence of disease. This is comparable to the long-term survival rate in osteosarcoma. The five-year survival rate is also comparable to that of fibrosarcoma of bone.

Original languageEnglish
Pages (from-to)698-707
Number of pages10
JournalCancer
Volume49
Issue number4
StatePublished - Jan 1 1982

Fingerprint

Malignant Fibrous Histiocytoma
Fibrosarcoma
Osteosarcoma
Bone and Bones
Neoplasm Metastasis
Neoplasms
Lung

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Primary malignant fibrous histiocytoma of bone : Report of six cases with ultrastructural study and analysis of the literature. / Ghandur-Mnaymneh, L.; Zych, Gregory A; Mnaymneh, W.

In: Cancer, Vol. 49, No. 4, 01.01.1982, p. 698-707.

Research output: Contribution to journalArticle

@article{cec5fbcd0a414eb1aa141e24917532e6,
title = "Primary malignant fibrous histiocytoma of bone: Report of six cases with ultrastructural study and analysis of the literature",
abstract = "Six cases of malignant fibrous histiocytoma (MFH) primary in bone were studied clinicopathologically with ultrastructural study of three. The histologic differentiation of MFH from osteosarcoma and from fibrosarcoma is discussed. Two of the six cases had highly malignant tumors histologically designated as Grade III and IV; one died with diffuse metastatic disease eight months after diagnosis and the second developed pulmonary metastases within ten months. Review of the literature revealed that 45 of the total 119 reported cases had been followed for less than five years; these cases were considered unevaluable for assessing biologic behavior. The remaining 74 cases, followed for more than five years or until death, showed a 36.5{\%} five-year survival rate. All but one of the cases which developed metastasis within five years did so within the first two years. It is therefore concluded that MFH of bone is a rapidly metastasizing tumor with a relatively low five-year survival rate. Paradoxically, 13 of these 74 cases (17.6{\%}) survived between five and 38 years with no evidence of disease. This is comparable to the long-term survival rate in osteosarcoma. The five-year survival rate is also comparable to that of fibrosarcoma of bone.",
author = "L. Ghandur-Mnaymneh and Zych, {Gregory A} and W. Mnaymneh",
year = "1982",
month = "1",
day = "1",
language = "English",
volume = "49",
pages = "698--707",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Primary malignant fibrous histiocytoma of bone

T2 - Report of six cases with ultrastructural study and analysis of the literature

AU - Ghandur-Mnaymneh, L.

AU - Zych, Gregory A

AU - Mnaymneh, W.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Six cases of malignant fibrous histiocytoma (MFH) primary in bone were studied clinicopathologically with ultrastructural study of three. The histologic differentiation of MFH from osteosarcoma and from fibrosarcoma is discussed. Two of the six cases had highly malignant tumors histologically designated as Grade III and IV; one died with diffuse metastatic disease eight months after diagnosis and the second developed pulmonary metastases within ten months. Review of the literature revealed that 45 of the total 119 reported cases had been followed for less than five years; these cases were considered unevaluable for assessing biologic behavior. The remaining 74 cases, followed for more than five years or until death, showed a 36.5% five-year survival rate. All but one of the cases which developed metastasis within five years did so within the first two years. It is therefore concluded that MFH of bone is a rapidly metastasizing tumor with a relatively low five-year survival rate. Paradoxically, 13 of these 74 cases (17.6%) survived between five and 38 years with no evidence of disease. This is comparable to the long-term survival rate in osteosarcoma. The five-year survival rate is also comparable to that of fibrosarcoma of bone.

AB - Six cases of malignant fibrous histiocytoma (MFH) primary in bone were studied clinicopathologically with ultrastructural study of three. The histologic differentiation of MFH from osteosarcoma and from fibrosarcoma is discussed. Two of the six cases had highly malignant tumors histologically designated as Grade III and IV; one died with diffuse metastatic disease eight months after diagnosis and the second developed pulmonary metastases within ten months. Review of the literature revealed that 45 of the total 119 reported cases had been followed for less than five years; these cases were considered unevaluable for assessing biologic behavior. The remaining 74 cases, followed for more than five years or until death, showed a 36.5% five-year survival rate. All but one of the cases which developed metastasis within five years did so within the first two years. It is therefore concluded that MFH of bone is a rapidly metastasizing tumor with a relatively low five-year survival rate. Paradoxically, 13 of these 74 cases (17.6%) survived between five and 38 years with no evidence of disease. This is comparable to the long-term survival rate in osteosarcoma. The five-year survival rate is also comparable to that of fibrosarcoma of bone.

UR - http://www.scopus.com/inward/record.url?scp=0020035433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020035433&partnerID=8YFLogxK

M3 - Article

C2 - 6948602

AN - SCOPUS:0020035433

VL - 49

SP - 698

EP - 707

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 4

ER -