Primary lymphoma of peripheral nerve: Report of four cases

Joseph Misdraji, Yasushi Ino, David N. Louis, Andrew Rosenberg, E. Antonio Chiocca, Nancy L. Harris

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Lymphoma presenting as a solitary tumor of peripheral nerve is exceedingly rare, with only six previously reported cases. The authors describe an additional four cases of primary lymphoma of peripheral nerve involving the sciatic nerve (two cases), the radial nerve, and the sympathetic chain and spinal nerve. The patients were two men and two women with an average age of 55.5 years. All tumors were high-grade B-cell lymphomas. Two patients experienced relapse of disease with involvement of other nervous system sites and died of lymphoma. One patient is alive with stable local disease at 57 months. The fourth patient is alive with no evidence of disease at 54 months. Expression of neural cell adhesion molecule (CD56) has been reported to correlate with an increased incidence of central nervous system involvement in peripheral T-cell lymphoma; all their cases were CD56 negative. Recent reports indicate a high proportion of primary brain lymphomas show loss of CDKN2A/p16 gene expression. Therefore, CDKN2A/p16 was evaluated in their patients both by polymerase chain reaction and by immunohistochemistry for the p16 protein. The authors found homozygous deletion of the CDKN2A/p16 gene in one of three patients studied, confirmed immunohistochemically by absent staining for p 16. The fourth patient showed absent staining for p16, suggesting inactivation of the gene in this case as well. The two patients with p16 loss both died of lymphoma, whereas the two patients with normal p16 expression are alive. Primary lymphoma of peripheral nerve is a rare neoplasm, usually of large B-cell type, has a variable prognosis, and appears to have less consistent loss of p16 expression than primary central nervous system lymphoma.

Original languageEnglish
Pages (from-to)1257-1265
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume24
Issue number9
DOIs
StatePublished - Sep 18 2000
Externally publishedYes

Fingerprint

Peripheral Nerves
Lymphoma
p16 Genes
Peripheral Nervous System Neoplasms
Central Nervous System
Staining and Labeling
Peripheral T-Cell Lymphoma
Radial Nerve
Neural Cell Adhesion Molecules
Spinal Nerves
Gene Silencing
B-Cell Lymphoma
Sciatic Nerve
Non-Hodgkin's Lymphoma
Nervous System
Neoplasms
B-Lymphocytes
Immunohistochemistry
Gene Expression
Recurrence

Keywords

  • CDKN2A/p 16p16
  • Diffuse, large B-cell lymphoma
  • Malignant lymphoma
  • Neurolymphomatosis
  • Peripheral nervous system

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Primary lymphoma of peripheral nerve : Report of four cases. / Misdraji, Joseph; Ino, Yasushi; Louis, David N.; Rosenberg, Andrew; Chiocca, E. Antonio; Harris, Nancy L.

In: American Journal of Surgical Pathology, Vol. 24, No. 9, 18.09.2000, p. 1257-1265.

Research output: Contribution to journalArticle

Misdraji, Joseph ; Ino, Yasushi ; Louis, David N. ; Rosenberg, Andrew ; Chiocca, E. Antonio ; Harris, Nancy L. / Primary lymphoma of peripheral nerve : Report of four cases. In: American Journal of Surgical Pathology. 2000 ; Vol. 24, No. 9. pp. 1257-1265.
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