Abstract
Background Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically. Cases A 41 year-old with an adnexal mass underwent surgical staging for a stage IA ovarian melanoma. Imaging revealed a brain metastasis treated with radiation. Subsequent nodal recurrence was treated with immune and targeted therapies. She is alive with disease at 61 months follow-up. A 54 year-old presented after endocervical melanoma was diagnosed with polypectomy. She underwent radical hysterectomy, lymphadenectomy, and adjuvant brachytherapy. Immediate post-treatment imaging revealed widespread liver and pulmonary metastasis, currently being treated with ipilimumab. Conclusion Immunohistochemistry can facilitate the diagnosis of gynecologic melanoma, and multidisciplinary treatment is recommended.
Original language | English (US) |
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Pages (from-to) | 31-33 |
Number of pages | 3 |
Journal | Gynecologic Oncology Reports |
Volume | 11 |
DOIs | |
State | Published - Jan 1 2015 |
Keywords
- Cervical melanoma
- Immunotherapy
- Multidisciplinary treatment
- Ovarian melanoma
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology