Abstract
Background Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically. Cases A 41 year-old with an adnexal mass underwent surgical staging for a stage IA ovarian melanoma. Imaging revealed a brain metastasis treated with radiation. Subsequent nodal recurrence was treated with immune and targeted therapies. She is alive with disease at 61 months follow-up. A 54 year-old presented after endocervical melanoma was diagnosed with polypectomy. She underwent radical hysterectomy, lymphadenectomy, and adjuvant brachytherapy. Immediate post-treatment imaging revealed widespread liver and pulmonary metastasis, currently being treated with ipilimumab. Conclusion Immunohistochemistry can facilitate the diagnosis of gynecologic melanoma, and multidisciplinary treatment is recommended.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 31-33 |
| Number of pages | 3 |
| Journal | Gynecologic Oncology Case Reports |
| Volume | 11 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
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Keywords
- Cervical melanoma
- Immunotherapy
- Multidisciplinary treatment
- Ovarian melanoma
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Oncology
Cite this
Primary gynecologic melanoma : A report of two unusual cases. / Berger, Jessica L.; Samrao, Daman; Huang, Marilyn; Olawaiye, Alexander B.
In: Gynecologic Oncology Case Reports, Vol. 11, 01.01.2015, p. 31-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary gynecologic melanoma
T2 - A report of two unusual cases
AU - Berger, Jessica L.
AU - Samrao, Daman
AU - Huang, Marilyn
AU - Olawaiye, Alexander B.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically. Cases A 41 year-old with an adnexal mass underwent surgical staging for a stage IA ovarian melanoma. Imaging revealed a brain metastasis treated with radiation. Subsequent nodal recurrence was treated with immune and targeted therapies. She is alive with disease at 61 months follow-up. A 54 year-old presented after endocervical melanoma was diagnosed with polypectomy. She underwent radical hysterectomy, lymphadenectomy, and adjuvant brachytherapy. Immediate post-treatment imaging revealed widespread liver and pulmonary metastasis, currently being treated with ipilimumab. Conclusion Immunohistochemistry can facilitate the diagnosis of gynecologic melanoma, and multidisciplinary treatment is recommended.
AB - Background Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically. Cases A 41 year-old with an adnexal mass underwent surgical staging for a stage IA ovarian melanoma. Imaging revealed a brain metastasis treated with radiation. Subsequent nodal recurrence was treated with immune and targeted therapies. She is alive with disease at 61 months follow-up. A 54 year-old presented after endocervical melanoma was diagnosed with polypectomy. She underwent radical hysterectomy, lymphadenectomy, and adjuvant brachytherapy. Immediate post-treatment imaging revealed widespread liver and pulmonary metastasis, currently being treated with ipilimumab. Conclusion Immunohistochemistry can facilitate the diagnosis of gynecologic melanoma, and multidisciplinary treatment is recommended.
KW - Cervical melanoma
KW - Immunotherapy
KW - Multidisciplinary treatment
KW - Ovarian melanoma
UR - http://www.scopus.com/inward/record.url?scp=84964810659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964810659&partnerID=8YFLogxK
U2 - 10.1016/j.gore.2015.01.003
DO - 10.1016/j.gore.2015.01.003
M3 - Article
AN - SCOPUS:84964810659
VL - 11
SP - 31
EP - 33
JO - Gynecologic Oncology Case Reports
JF - Gynecologic Oncology Case Reports
SN - 2211-338X
ER -