Primary gynecologic melanoma: A report of two unusual cases

Jessica L. Berger, Daman Samrao, Marilyn Huang, Alexander B. Olawaiye

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically. Cases A 41 year-old with an adnexal mass underwent surgical staging for a stage IA ovarian melanoma. Imaging revealed a brain metastasis treated with radiation. Subsequent nodal recurrence was treated with immune and targeted therapies. She is alive with disease at 61 months follow-up. A 54 year-old presented after endocervical melanoma was diagnosed with polypectomy. She underwent radical hysterectomy, lymphadenectomy, and adjuvant brachytherapy. Immediate post-treatment imaging revealed widespread liver and pulmonary metastasis, currently being treated with ipilimumab. Conclusion Immunohistochemistry can facilitate the diagnosis of gynecologic melanoma, and multidisciplinary treatment is recommended.

Original languageEnglish (US)
Pages (from-to)31-33
Number of pages3
JournalGynecologic Oncology Reports
StatePublished - Jan 1 2015
Externally publishedYes


  • Cervical melanoma
  • Immunotherapy
  • Multidisciplinary treatment
  • Ovarian melanoma

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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