Primary gastrointestinal tract lymphoma in the pediatric patient

Review of 265 patients from the SEER registry

Noor Kassira, Felipe E. Pedroso, Michael C. Cheung, Leonidas G. Koniaris, Juan E Sola

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective: The objective of this study is to determine outcomes of pediatric patients with primary gastrointestinal tract lymphoma (PGTL) and the impact of surgery or radiation on survival. Methods: The Surveillance, Epidemiology, and End Result database was queried from 1973 to 2006 for patients younger than 20 years with PGTL. Results: 265 patients with PGTL were identified. Overall 5- and 10-year survivals were 84% and 83%, respectively. Tumors of the stomach (9%) and rectum/anus (2%) had the worst and best 10-year survivals, respectively (59% vs 100%, P =.023). There was no significant difference in 10-year survival for patients younger than 10 years of age who had surgical extirpation (83% vs 85% no surgery, P =.958) or radiotherapy (76% vs 85% no radiotherapy, P =.532). However, there was a significantly decreased 10-year survival in patients 10 years or older who had surgical extirpation (79% vs 100% no surgery, P =.013) or radiotherapy (49% vs 87% no radiotherapy, P =.001). Under multivariate analysis, tumor location was an independent predictor of improved survival (small bowel, HR 0.21, P =.002; large bowel, HR 0.23, P =.004). Conclusion: We found no significant survival advantage for surgical extirpation or radiotherapy in patients younger than 10 years with PGTL, whereas either treatment modality was associated with lower survival in patients 10 years or older.

Original languageEnglish
Pages (from-to)1956-1964
Number of pages9
JournalJournal of Pediatric Surgery
Volume46
Issue number10
DOIs
StatePublished - Oct 1 2011

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Registries
Gastrointestinal Tract
Lymphoma
Pediatrics
Survival
Radiotherapy
Anal Canal
Rectum
Neoplasms
Stomach
Epidemiology
Multivariate Analysis
Databases
Radiation

Keywords

  • Gastrointestinal
  • Lymphoma
  • Outcomes
  • Pediatrics
  • SEER
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Primary gastrointestinal tract lymphoma in the pediatric patient : Review of 265 patients from the SEER registry. / Kassira, Noor; Pedroso, Felipe E.; Cheung, Michael C.; Koniaris, Leonidas G.; Sola, Juan E.

In: Journal of Pediatric Surgery, Vol. 46, No. 10, 01.10.2011, p. 1956-1964.

Research output: Contribution to journalArticle

Kassira, Noor ; Pedroso, Felipe E. ; Cheung, Michael C. ; Koniaris, Leonidas G. ; Sola, Juan E. / Primary gastrointestinal tract lymphoma in the pediatric patient : Review of 265 patients from the SEER registry. In: Journal of Pediatric Surgery. 2011 ; Vol. 46, No. 10. pp. 1956-1964.
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