Primary choriocarcinoma of the lung: Report of a case treated with intensive multimodality therapy and review of the literature

Kasi S. Sridhar, Mario J. Saldana, Richard J. Thurer, Edward J. Beattie

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Primary choriocarcinomas of the lung are extremely rare. Like choriocarcinomas elsewhere, they possess rapid growth ability and a high propensity to metastasize. There is minimal information available on the treatment of lung choriocarcinoma. In the case reported herein, neoadjuvant chemotherapy with 5-fluorouracil (5-FU) infusion, etoposide, and cisplatin induced a partial response permitting complete excision of a massive tumor of the right upper lobe involving the chest wall and superior vena cava. The patient relapsed with a metastasis to the brain that was surgically excised. Contralateral lung metastases were soon noted and responded well to systemic chemotherapy; yet the patient died of a new brain metastasis. To our knowledge, this is the first example of a primary choriocarcinoma of the lung treated with intensive multimodality therapy. The latter seems to offer a potential benefit if certain guidelines are followed.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalJournal of surgical oncology
Volume41
Issue number2
DOIs
StatePublished - Jun 1989

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Keywords

  • brain metastasis
  • neoadjuvant chemotherapy
  • pre‐operative chemotherapy
  • superior vena caval syndrome

ASJC Scopus subject areas

  • Surgery
  • Oncology

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