Primary choriocarcinoma of the lung

Report of a case treated with intensive multimodality therapy and review of the literature

K. S. Sridhar, M. J. Saldana, Richard J Thurer, E. J. Beattie

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Primary choriocarcinomas of the lung are extremely rare. Like choriocarcinomas elsewhere, they possess rapid growth ability and a high propensity to metastasize. There is minimal information available on the treatment of lung choriocarcinoma. In the case reported herein, neoadjuvant chemotherapy with 5-fluorouracil (5-FU) infusion, etoposide, and cisplatin induced a partial response permitting complete excision of a massive tumor of the right upper lobe involving the chest wall and superior vena cava. The patient relapsed with a metastasis to the brain that was surgically excised. Contralateral lung metastases were soon noted and responded well to systemic chemotherapy; yet the patient died of a new brain metastasis. To our knowledge, this is the first example of a primary choriocarcinoma of the lung treated with intensive multimodality therapy. The latter seems to offer a potential benefit if certain guidelines are followed.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalJournal of Surgical Oncology
Volume41
Issue number2
StatePublished - Jan 1 1989

Fingerprint

Choriocarcinoma
Lung
Neoplasm Metastasis
Drug Therapy
Superior Vena Cava
Brain
Thoracic Wall
Etoposide
Therapeutics
Fluorouracil
Cisplatin
Guidelines
Growth
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Primary choriocarcinoma of the lung : Report of a case treated with intensive multimodality therapy and review of the literature. / Sridhar, K. S.; Saldana, M. J.; Thurer, Richard J; Beattie, E. J.

In: Journal of Surgical Oncology, Vol. 41, No. 2, 01.01.1989, p. 93-97.

Research output: Contribution to journalArticle

Sridhar, K. S. ; Saldana, M. J. ; Thurer, Richard J ; Beattie, E. J. / Primary choriocarcinoma of the lung : Report of a case treated with intensive multimodality therapy and review of the literature. In: Journal of Surgical Oncology. 1989 ; Vol. 41, No. 2. pp. 93-97.
@article{f65a8192f3a14b4eadc3f9a95bb94485,
title = "Primary choriocarcinoma of the lung: Report of a case treated with intensive multimodality therapy and review of the literature",
abstract = "Primary choriocarcinomas of the lung are extremely rare. Like choriocarcinomas elsewhere, they possess rapid growth ability and a high propensity to metastasize. There is minimal information available on the treatment of lung choriocarcinoma. In the case reported herein, neoadjuvant chemotherapy with 5-fluorouracil (5-FU) infusion, etoposide, and cisplatin induced a partial response permitting complete excision of a massive tumor of the right upper lobe involving the chest wall and superior vena cava. The patient relapsed with a metastasis to the brain that was surgically excised. Contralateral lung metastases were soon noted and responded well to systemic chemotherapy; yet the patient died of a new brain metastasis. To our knowledge, this is the first example of a primary choriocarcinoma of the lung treated with intensive multimodality therapy. The latter seems to offer a potential benefit if certain guidelines are followed.",
author = "Sridhar, {K. S.} and Saldana, {M. J.} and Thurer, {Richard J} and Beattie, {E. J.}",
year = "1989",
month = "1",
day = "1",
language = "English",
volume = "41",
pages = "93--97",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Primary choriocarcinoma of the lung

T2 - Report of a case treated with intensive multimodality therapy and review of the literature

AU - Sridhar, K. S.

AU - Saldana, M. J.

AU - Thurer, Richard J

AU - Beattie, E. J.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Primary choriocarcinomas of the lung are extremely rare. Like choriocarcinomas elsewhere, they possess rapid growth ability and a high propensity to metastasize. There is minimal information available on the treatment of lung choriocarcinoma. In the case reported herein, neoadjuvant chemotherapy with 5-fluorouracil (5-FU) infusion, etoposide, and cisplatin induced a partial response permitting complete excision of a massive tumor of the right upper lobe involving the chest wall and superior vena cava. The patient relapsed with a metastasis to the brain that was surgically excised. Contralateral lung metastases were soon noted and responded well to systemic chemotherapy; yet the patient died of a new brain metastasis. To our knowledge, this is the first example of a primary choriocarcinoma of the lung treated with intensive multimodality therapy. The latter seems to offer a potential benefit if certain guidelines are followed.

AB - Primary choriocarcinomas of the lung are extremely rare. Like choriocarcinomas elsewhere, they possess rapid growth ability and a high propensity to metastasize. There is minimal information available on the treatment of lung choriocarcinoma. In the case reported herein, neoadjuvant chemotherapy with 5-fluorouracil (5-FU) infusion, etoposide, and cisplatin induced a partial response permitting complete excision of a massive tumor of the right upper lobe involving the chest wall and superior vena cava. The patient relapsed with a metastasis to the brain that was surgically excised. Contralateral lung metastases were soon noted and responded well to systemic chemotherapy; yet the patient died of a new brain metastasis. To our knowledge, this is the first example of a primary choriocarcinoma of the lung treated with intensive multimodality therapy. The latter seems to offer a potential benefit if certain guidelines are followed.

UR - http://www.scopus.com/inward/record.url?scp=0024327749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024327749&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 93

EP - 97

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 2

ER -