Primary adenocarcinoma of the thymus: An immunohistochemical and molecular study with review of the literature

Maryam Maghbool, Mani Ramzi, Inga Nagel, Pablo Bejarano, Reiner Siebert, Abolfazl Saeedzadeh, Yahya Daneshbod

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Background: Primary adenocarcinoma of thymus is extremely rare. Case presentation. This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. Thymic cyst was associated with this tumor. Intestinal differentiation was confirmed by immunohistochemical stain with positivity for CDX-2, CK20, villin, MOC31 and focal positivity of CK7. Array comperative genomic hybridization (CGH) analysis showed a complex pattern of chromosomal imbalances including homozygous deletion at the HLA locus in chromosomal region 6p21.32. Conclusion: This rare tumor shows a similar genetic aberration with other studied thymic epithelial tumors.

Original languageEnglish (US)
Article number17
JournalBMC Clinical Pathology
Volume13
Issue number1
DOIs
StatePublished - 2013

Keywords

  • CGH array
  • Immunohistochemical study
  • Intestinal differentiation
  • Literature review
  • Molecular study
  • Primary adenocarcinoma
  • Thymic carcinoma
  • Thymoma
  • Thymus gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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    Maghbool, M., Ramzi, M., Nagel, I., Bejarano, P., Siebert, R., Saeedzadeh, A., & Daneshbod, Y. (2013). Primary adenocarcinoma of the thymus: An immunohistochemical and molecular study with review of the literature. BMC Clinical Pathology, 13(1), [17]. https://doi.org/10.1186/1472-6890-13-17