Primary adenocarcinoma of the thymus

An immunohistochemical and molecular study with review of the literature

Maryam Maghbool, Mani Ramzi, Inga Nagel, Pablo Bejarano, Reiner Siebert, Abolfazl Saeedzadeh, Yahya Daneshbod

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Primary adenocarcinoma of thymus is extremely rare. Case presentation. This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. Thymic cyst was associated with this tumor. Intestinal differentiation was confirmed by immunohistochemical stain with positivity for CDX-2, CK20, villin, MOC31 and focal positivity of CK7. Array comperative genomic hybridization (CGH) analysis showed a complex pattern of chromosomal imbalances including homozygous deletion at the HLA locus in chromosomal region 6p21.32. Conclusion: This rare tumor shows a similar genetic aberration with other studied thymic epithelial tumors.

Original languageEnglish
Article number17
JournalBMC Clinical Pathology
Volume13
Issue number1
DOIs
StatePublished - Jun 5 2013

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Thymus Gland
Adenocarcinoma
Mediastinal Cyst
Nucleic Acid Hybridization
Mucins
Neoplasms
Coloring Agents
ezrin
Thymic epithelial tumor

Keywords

  • CGH array
  • Immunohistochemical study
  • Intestinal differentiation
  • Literature review
  • Molecular study
  • Primary adenocarcinoma
  • Thymic carcinoma
  • Thymoma
  • Thymus gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Maghbool, M., Ramzi, M., Nagel, I., Bejarano, P., Siebert, R., Saeedzadeh, A., & Daneshbod, Y. (2013). Primary adenocarcinoma of the thymus: An immunohistochemical and molecular study with review of the literature. BMC Clinical Pathology, 13(1), [17]. https://doi.org/10.1186/1472-6890-13-17

Primary adenocarcinoma of the thymus : An immunohistochemical and molecular study with review of the literature. / Maghbool, Maryam; Ramzi, Mani; Nagel, Inga; Bejarano, Pablo; Siebert, Reiner; Saeedzadeh, Abolfazl; Daneshbod, Yahya.

In: BMC Clinical Pathology, Vol. 13, No. 1, 17, 05.06.2013.

Research output: Contribution to journalArticle

Maghbool, M, Ramzi, M, Nagel, I, Bejarano, P, Siebert, R, Saeedzadeh, A & Daneshbod, Y 2013, 'Primary adenocarcinoma of the thymus: An immunohistochemical and molecular study with review of the literature', BMC Clinical Pathology, vol. 13, no. 1, 17. https://doi.org/10.1186/1472-6890-13-17
Maghbool, Maryam ; Ramzi, Mani ; Nagel, Inga ; Bejarano, Pablo ; Siebert, Reiner ; Saeedzadeh, Abolfazl ; Daneshbod, Yahya. / Primary adenocarcinoma of the thymus : An immunohistochemical and molecular study with review of the literature. In: BMC Clinical Pathology. 2013 ; Vol. 13, No. 1.
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