A chronic schizophrenic patient received 30 mg fluphenazine hydrochloride (Prolixin®) PO and developed priapism. Urological examination and subsequent urological workup was negative, indentifying fluphenazine hydrochloride as the cause of the priapism. During the period of priapism evaluation, the patient developed a severe extrapyramidal reaction that was treated with diphenhydramine (Benadryl®) 50 mg IV push. There was remission of the extrapyramidal reaction in three minutes followed by resolution of the priapism. The rationale for the treatment of antipsychotic drug-induced priapism with anticholinergic drugs is discussed.
- fluphenazine, complications of
- priapism, cause of, fluphenazine
ASJC Scopus subject areas
- Emergency Medicine