Priapism resulting from fluphenazine hydrochloride treatment reversed by diphenhydramine

David A. Fishbain

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


A chronic schizophrenic patient received 30 mg fluphenazine hydrochloride (Prolixin®) PO and developed priapism. Urological examination and subsequent urological workup was negative, indentifying fluphenazine hydrochloride as the cause of the priapism. During the period of priapism evaluation, the patient developed a severe extrapyramidal reaction that was treated with diphenhydramine (Benadryl®) 50 mg IV push. There was remission of the extrapyramidal reaction in three minutes followed by resolution of the priapism. The rationale for the treatment of antipsychotic drug-induced priapism with anticholinergic drugs is discussed.

Original languageEnglish (US)
Pages (from-to)600-602
Number of pages3
JournalAnnals of Emergency Medicine
Issue number6
StatePublished - Jun 1985


  • fluphenazine, complications of
  • priapism, cause of, fluphenazine

ASJC Scopus subject areas

  • Emergency Medicine


Dive into the research topics of 'Priapism resulting from fluphenazine hydrochloride treatment reversed by diphenhydramine'. Together they form a unique fingerprint.

Cite this