Abstract
Excitotoxic mechanisms due to overactivity of the amino acid neurotransmitters glutamate and aspartate maybe responsible for brain damage after injury. In this review we examine ischaemia and shear injury, which are relevant to human head injury. The opportunities for treatment using glutamate antagonist drugs are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 49-55 |
| Number of pages | 7 |
| Journal | Acta Neurochirurgica, Supplement |
| Volume | 55 |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Clinical Neurology
Cite this
Prevention of post-traumatic excitotoxic brain damage with NMDA antagonist drugs : a new strategy for the nineties. / Bullock, Ross; Kuroda, Y.; Teasdale, G. M.; McCulloch, J.
In: Acta Neurochirurgica, Supplement, Vol. 55, 01.01.1992, p. 49-55.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevention of post-traumatic excitotoxic brain damage with NMDA antagonist drugs
T2 - a new strategy for the nineties.
AU - Bullock, Ross
AU - Kuroda, Y.
AU - Teasdale, G. M.
AU - McCulloch, J.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Excitotoxic mechanisms due to overactivity of the amino acid neurotransmitters glutamate and aspartate maybe responsible for brain damage after injury. In this review we examine ischaemia and shear injury, which are relevant to human head injury. The opportunities for treatment using glutamate antagonist drugs are discussed.
AB - Excitotoxic mechanisms due to overactivity of the amino acid neurotransmitters glutamate and aspartate maybe responsible for brain damage after injury. In this review we examine ischaemia and shear injury, which are relevant to human head injury. The opportunities for treatment using glutamate antagonist drugs are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0026619299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026619299&partnerID=8YFLogxK
M3 - Article
VL - 55
SP - 49
EP - 55
JO - Scientific Computing and Instrumentation
JF - Scientific Computing and Instrumentation
SN - 1078-8956
ER -