Prevention of post-traumatic excitotoxic brain damage with NMDA antagonist drugs: a new strategy for the nineties.

R. Bullock, Y. Kuroda, G. M. Teasdale, J. McCulloch

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

Excitotoxic mechanisms due to overactivity of the amino acid neurotransmitters glutamate and aspartate maybe responsible for brain damage after injury. In this review we examine ischaemia and shear injury, which are relevant to human head injury. The opportunities for treatment using glutamate antagonist drugs are discussed.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalActa neurochirurgica. Supplementum
Volume55
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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