Prevention of post-traumatic excitotoxic brain damage with NMDA antagonist drugs

a new strategy for the nineties.

Ross Bullock, Y. Kuroda, G. M. Teasdale, J. McCulloch

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Excitotoxic mechanisms due to overactivity of the amino acid neurotransmitters glutamate and aspartate maybe responsible for brain damage after injury. In this review we examine ischaemia and shear injury, which are relevant to human head injury. The opportunities for treatment using glutamate antagonist drugs are discussed.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalActa Neurochirurgica, Supplement
Volume55
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

brain damage
Excitatory Amino Acid Antagonists
N-Methylaspartate
Aspartic Acid
Neurotransmitter Agents
Amino acids
Glutamic Acid
Brain
glutamates
drugs
Amino Acids
Wounds and Injuries
Craniocerebral Trauma
Pharmaceutical Preparations
neurotransmitters
aspartates
ischemia
Ischemia
amino acids
shear

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Prevention of post-traumatic excitotoxic brain damage with NMDA antagonist drugs : a new strategy for the nineties. / Bullock, Ross; Kuroda, Y.; Teasdale, G. M.; McCulloch, J.

In: Acta Neurochirurgica, Supplement, Vol. 55, 01.01.1992, p. 49-55.

Research output: Contribution to journalArticle

@article{8c4b3e48cb6e449587bf17aed664e734,
title = "Prevention of post-traumatic excitotoxic brain damage with NMDA antagonist drugs: a new strategy for the nineties.",
abstract = "Excitotoxic mechanisms due to overactivity of the amino acid neurotransmitters glutamate and aspartate maybe responsible for brain damage after injury. In this review we examine ischaemia and shear injury, which are relevant to human head injury. The opportunities for treatment using glutamate antagonist drugs are discussed.",
author = "Ross Bullock and Y. Kuroda and Teasdale, {G. M.} and J. McCulloch",
year = "1992",
month = "1",
day = "1",
language = "English",
volume = "55",
pages = "49--55",
journal = "Scientific Computing and Instrumentation",
issn = "1078-8956",
publisher = "Springer Wien",

}

TY - JOUR

T1 - Prevention of post-traumatic excitotoxic brain damage with NMDA antagonist drugs

T2 - a new strategy for the nineties.

AU - Bullock, Ross

AU - Kuroda, Y.

AU - Teasdale, G. M.

AU - McCulloch, J.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Excitotoxic mechanisms due to overactivity of the amino acid neurotransmitters glutamate and aspartate maybe responsible for brain damage after injury. In this review we examine ischaemia and shear injury, which are relevant to human head injury. The opportunities for treatment using glutamate antagonist drugs are discussed.

AB - Excitotoxic mechanisms due to overactivity of the amino acid neurotransmitters glutamate and aspartate maybe responsible for brain damage after injury. In this review we examine ischaemia and shear injury, which are relevant to human head injury. The opportunities for treatment using glutamate antagonist drugs are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0026619299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026619299&partnerID=8YFLogxK

M3 - Article

VL - 55

SP - 49

EP - 55

JO - Scientific Computing and Instrumentation

JF - Scientific Computing and Instrumentation

SN - 1078-8956

ER -