Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin.

R. E. Marx, R. P. Johnson, S. N. Kline

Research output: Contribution to journalArticlepeer-review

350 Scopus citations

Abstract

A prospective randomized trial comparing hyperbaric oxygen and systemic antibiotics in the prevention of osteoradionecrosis was presented. The results indicated, in a high-risk population who required tooth removal in irradiated mandibles, that up-front hyperbaric oxygen produced an incidence of osteoradionecrosis of 5.4% as compared with the antibiotic group of 29.9% (P = .005). Hyperbaric oxygen should be considered a prophylactic measure when post-irradiation dental care involving trauma to tissue is necessary.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalJournal of the American Dental Association (1939)
Volume111
Issue number1
DOIs
StatePublished - Jul 1985
Externally publishedYes

ASJC Scopus subject areas

  • Dentistry(all)

Fingerprint Dive into the research topics of 'Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin.'. Together they form a unique fingerprint.

Cite this