Prevention of implantation by [d-trp6]-LH-RH IN the rat

Comparative study with the effects of large doses of hcg on pregnancy

A. Arimura, E. Pedroza, J. Vilchez-Martinez, Andrew V Schally

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Effect of large doses of [D-Trp6]-LH-RH and HCG on implantation of fertilized ova was examined in the rat. Subcutaneous administration of 6ug[D-Trp6]-LH-RH per day from days 1 to 5 of pregnancy by an implanted minipump completely prevented the implantation of fertilized ova associated with a dramatic reduction of plasma progesterone on days 4 and 8, with a slight reduction of estradiol on day 4. There was no balooning of the uterus in the exploratory laparotomy on days 8 and 14. Administration of 1000 U of HCG daily from days 1 to 5 partially prevented implantation and completely terminated gestation. However, plasma progesterone and estradiol levels did not differ from those in the control animals. Ovaries in the [D-Trp6]-LH-RH treated rats appeared to be the same in size as those of the control pregnant rats, whereas the ovaries of the HCG-treated rats were hypertrophied. The results suggest that [D-Trp6]-LH-RH prevents nidation through a mechanism different from that for the adverse effect of excess HCG on pregnancy.

Original languageEnglish
Pages (from-to)357-366
Number of pages10
JournalEndocrine Research
Volume4
Issue number6
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

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Gonadotropin-Releasing Hormone
Pregnancy
Zygote
Progesterone
Ovary
Estradiol
Laparotomy
Uterus

ASJC Scopus subject areas

  • Endocrinology
  • Medicine(all)

Cite this

Prevention of implantation by [d-trp6]-LH-RH IN the rat : Comparative study with the effects of large doses of hcg on pregnancy. / Arimura, A.; Pedroza, E.; Vilchez-Martinez, J.; Schally, Andrew V.

In: Endocrine Research, Vol. 4, No. 6, 01.01.1977, p. 357-366.

Research output: Contribution to journalArticle

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