Prevention of chemotherapy-induced alopecia in rodent models

Joaquin J Jimenez, Stephen M. Roberts, Jessica Mejia, Lucia M. Mauro, John W. Munson, George Elgart, Elizabeth Alvarez Connelly, Qingbin Chen, Jiangying Zou, Carlos Goldenberg, Richard Voellmy

Research output: Contribution to journalArticle

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Abstract

Alopecia (hair loss) is experienced by thousands of cancer patients every year. Substantial-to-severe alopecia is induced by anthracyclines (e.g., adriamycin), taxanes (e.g., taxol), alkylating compounds (e.g., cyclophosphamide), and the topisomerase inhibitor etoposide, agents that are widely used in the treatment of leukemias and breast, lung, ovarian, and bladder cancers. Currently, no treatment appears to be generally effective in reliably preventing this secondary effect of chemotherapy. We observed in experiments using different rodent models that localized administration of heat or subcutaneous/intradermal injection of geldanamycin or 17-(allylamino)-17- demethoxygeldanamycin induced a stress protein response in hair follicles and effectively prevented alopecia from adriamycin, cyclophosphamide, taxol, and etoposide. Model tumor therapy experiments support the presumption that such localized hair-saving treatment does not negatively affect chemotherapy efficacy.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalCell Stress and Chaperones
Volume13
Issue number1
DOIs
StatePublished - Mar 1 2008

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Chemotherapy
Alopecia
Etoposide
tanespimycin
Paclitaxel
Doxorubicin
Cyclophosphamide
Rodentia
Drug Therapy
Taxoids
Anthracyclines
Heat-Shock Proteins
Tumors
Experiments
Intradermal Injections
Hair Follicle
Subcutaneous Injections
Therapeutics
Urinary Bladder Neoplasms
Ovarian Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Prevention of chemotherapy-induced alopecia in rodent models. / Jimenez, Joaquin J; Roberts, Stephen M.; Mejia, Jessica; Mauro, Lucia M.; Munson, John W.; Elgart, George; Connelly, Elizabeth Alvarez; Chen, Qingbin; Zou, Jiangying; Goldenberg, Carlos; Voellmy, Richard.

In: Cell Stress and Chaperones, Vol. 13, No. 1, 01.03.2008, p. 31-38.

Research output: Contribution to journalArticle

Jimenez, JJ, Roberts, SM, Mejia, J, Mauro, LM, Munson, JW, Elgart, G, Connelly, EA, Chen, Q, Zou, J, Goldenberg, C & Voellmy, R 2008, 'Prevention of chemotherapy-induced alopecia in rodent models', Cell Stress and Chaperones, vol. 13, no. 1, pp. 31-38. https://doi.org/10.1007/s12192-007-0005-1
Jimenez, Joaquin J ; Roberts, Stephen M. ; Mejia, Jessica ; Mauro, Lucia M. ; Munson, John W. ; Elgart, George ; Connelly, Elizabeth Alvarez ; Chen, Qingbin ; Zou, Jiangying ; Goldenberg, Carlos ; Voellmy, Richard. / Prevention of chemotherapy-induced alopecia in rodent models. In: Cell Stress and Chaperones. 2008 ; Vol. 13, No. 1. pp. 31-38.
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AU - Connelly, Elizabeth Alvarez

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