Prevention and reversal of type 1 diabetes-past challenges and future opportunities

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Over the past three decades there have been a number of clinical trials directed at interdicting the type 1 diabetes (T1D) disease process in an attempt to prevent the development of the disease in those at increased risk or to stabilize-potentially even reverse-the disease in people with T1D, usually of recent onset. Unfortunately, to date there has been no prevention trial that has resulted in delay or prevention of T1D. And, trials in people with T1D have had mixed results with some showing promise with at least transient improvement in β-cell function compared with randomized control groups, while others have failed to slow the decline in β-cell function when compared with placebo. This Perspective will assess the past and present challenges in this effort and provide an outline for potential future opportunities.

Original languageEnglish (US)
Pages (from-to)997-1007
Number of pages11
JournalDiabetes care
Issue number6
StatePublished - Jun 2015

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


Dive into the research topics of 'Prevention and reversal of type 1 diabetes-past challenges and future opportunities'. Together they form a unique fingerprint.

Cite this