Preventing pediatric cardiomyopathy: A 2015 outlook

Paul F. Kantor, Jake A. Kleinman, Thomas D. Ryan, Ivan Wilmot, Warren A. Zuckerman, Linda J. Addonizio, Melanie D. Everitt, John L. Jefferies, Teresa M. Lee, Jeffrey A. Towbin, James D. Wilkinson, Steven E. Lipshultz

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Cardiomyopathies in children encompass a broad range of diseases, both genetic and acquired, which manifest as a primary cardiac disorder or as a cardiomyopathy secondary to systemic disease. The burden of this group of disorders is substantial, and growing on a global scale. The availability of disease altering treatments is limited, and therefore a focused review on the prevention of cardiomyopathies is justified. In this review, we address the prevention of cardiomyopathy in children by dealing with the root causes of disease at a molecular, clinical and population level. Recent years have yielded promising returns in basic research related to gene-targeted therapy, specific anti-viral therapies and modification of the effects of cardiotoxic drugs. Much work remains to be done in the fields of vaccine development, public health and adoption of available treatments. Effective research in this field will require that diagnostic methods are both refined, and made available more broadly, from imaging to gene testing. Much of our knowledge today is derived from the use of registries, which have successfully catalogued the detailed phenotype of affected patients, and provided long-term longitudinal follow up of affected individuals.

Original languageEnglish (US)
Pages (from-to)321-339
Number of pages19
JournalExpert Review of Cardiovascular Therapy
Issue number3
StatePublished - Mar 3 2016


  • Cardiomyopathy
  • Cardiotoxicity
  • Genetics
  • Myocarditis
  • Pediatric

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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