Prevalence of Haarlem I and Beijing types of Mycobacterium tuberculosis strains in Iranian and Afghan MDR-TB patients

Parissa Farnia, Mohamad Reza Masjedi, Mehdi Mirsaeidi, Foroozan Mohammadi, Jallaledin-Ghanavi, Veronique Vincent, Moslem Bahadori, Ali Akbar Velayati

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Objectives: This survey identified the spoligopatterns of Mycobacterium tuberculosis strains with an international designation responsible for transmission and prevalence of Multi-Drug Resistance Tuberculosis (MDR-TB) among native and immigrant population of Tehran (2000-2005). Methods: The spacer oligonucleotides typing was performed on 263 M. tuberculosis strains isolated from verified cases of MDR-TB. Clinical and demographical data of patients were collected using traditional methods. Results: Classical epidemiological investigation revealed that out of 263 MDR-TB cases, 175, 66.5% were isolated from Afghan immigrants. In both communities, majority of MDR-TB cases had either previous history of TB (107, 40.6%) or had a close contact (84, 31.9%). By spoligotyping, 27 distinct patterns were observed, 253 clinical isolates were grouped in 17 clusters (62.9%) and 10 isolates displayed an orphan pattern (37%). Based on an international spoligotype database, Haarlem I (85, 33.5%), Beijing (52, 20.5%), Central Asia (32, 12.1%), and EAI (21, 8.3%) were the major identified super families. Although, 76.9% of the Beijing genotypes and 100% of ST253 strains (that was prevalent through former Soviet Union) were isolated from Afghan patients only. The linkage patterns between 30 Iranian and Afghan patients were observed. Conclusion: The study highlighted the epidemic potential of Haarlem I and Beijing genotypes among MDR-TB cases in Tehran territory.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalJournal of Infection
Volume53
Issue number5
DOIs
StatePublished - Nov 2006
Externally publishedYes

Fingerprint

Multiple Drug Resistance
Mycobacterium tuberculosis
Tuberculosis
Genotype
Central Asia
Orphaned Children
USSR
Oligonucleotides
Beijing
Databases
Population

Keywords

  • Beijing
  • MDR-TB
  • Spoligotyping

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Prevalence of Haarlem I and Beijing types of Mycobacterium tuberculosis strains in Iranian and Afghan MDR-TB patients. / Farnia, Parissa; Masjedi, Mohamad Reza; Mirsaeidi, Mehdi; Mohammadi, Foroozan; Jallaledin-Ghanavi; Vincent, Veronique; Bahadori, Moslem; Velayati, Ali Akbar.

In: Journal of Infection, Vol. 53, No. 5, 11.2006, p. 331-336.

Research output: Contribution to journalArticle

Farnia, P, Masjedi, MR, Mirsaeidi, M, Mohammadi, F, Jallaledin-Ghanavi, Vincent, V, Bahadori, M & Velayati, AA 2006, 'Prevalence of Haarlem I and Beijing types of Mycobacterium tuberculosis strains in Iranian and Afghan MDR-TB patients', Journal of Infection, vol. 53, no. 5, pp. 331-336. https://doi.org/10.1016/j.jinf.2005.12.020
Farnia, Parissa ; Masjedi, Mohamad Reza ; Mirsaeidi, Mehdi ; Mohammadi, Foroozan ; Jallaledin-Ghanavi ; Vincent, Veronique ; Bahadori, Moslem ; Velayati, Ali Akbar. / Prevalence of Haarlem I and Beijing types of Mycobacterium tuberculosis strains in Iranian and Afghan MDR-TB patients. In: Journal of Infection. 2006 ; Vol. 53, No. 5. pp. 331-336.
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AU - Mohammadi, Foroozan

AU - Jallaledin-Ghanavi,

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AB - Objectives: This survey identified the spoligopatterns of Mycobacterium tuberculosis strains with an international designation responsible for transmission and prevalence of Multi-Drug Resistance Tuberculosis (MDR-TB) among native and immigrant population of Tehran (2000-2005). Methods: The spacer oligonucleotides typing was performed on 263 M. tuberculosis strains isolated from verified cases of MDR-TB. Clinical and demographical data of patients were collected using traditional methods. Results: Classical epidemiological investigation revealed that out of 263 MDR-TB cases, 175, 66.5% were isolated from Afghan immigrants. In both communities, majority of MDR-TB cases had either previous history of TB (107, 40.6%) or had a close contact (84, 31.9%). By spoligotyping, 27 distinct patterns were observed, 253 clinical isolates were grouped in 17 clusters (62.9%) and 10 isolates displayed an orphan pattern (37%). Based on an international spoligotype database, Haarlem I (85, 33.5%), Beijing (52, 20.5%), Central Asia (32, 12.1%), and EAI (21, 8.3%) were the major identified super families. Although, 76.9% of the Beijing genotypes and 100% of ST253 strains (that was prevalent through former Soviet Union) were isolated from Afghan patients only. The linkage patterns between 30 Iranian and Afghan patients were observed. Conclusion: The study highlighted the epidemic potential of Haarlem I and Beijing genotypes among MDR-TB cases in Tehran territory.

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