Prevalence of Foveal Lesions in Type 1 and Type 2 Usher's Syndrome

Gerald A. Fishman, Robert J. Anderson, Byron L. Lam, Deborah J. Derlacki

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Purpose: To evaluate possible differences in the prevalence of clinically detectable foveal lesions between patients with type 1 and type 2 Usher's syndrome. Methods: Records of 48 patients with type 1 and 98 patients with type 2 Usher's syndrome were retrospectively evaluated for the presence of a foveal lesion. The age, gender, and racial distribution of patients were similar in the two subtypes. Two investigators reviewed fundus photographs from all patients and, when available, fluorescein angiograms. Results: In the 48 patients with type 1 Usher's syndrome, 30 (62%) showed a clinically apparent atrophic- or cystic-appearing foveal lesion, whereas in the 98 patients with type 2 Usher's syndrome, 33 (34%) had either an atrophic- or a cystic-appearing foveal lesion. Logistic regression analysis showed that the probability of exhibiting a foveal lesion in both type 1 and type 2 Usher's syndrome increases with age and that patients with type 1 Usher's syndrome are more likely to have a foveal lesion than are patients with type 2 Usher's syndrome. Conclusions: Patients with type 1 Usher's syndrome show a greater probability of having either an atrophic-or cystic-appearing foveal lesion than do patients with type 2 Usher's syndrome. This higher prevalence of foveal lesions is consistent with a previous observation that the severity of visual acuity impairment with age is greater for patients with type 1 than type 2 Usher's syndrome. These data are useful in counseling such patients as to their prognosis for central visual function.

Original languageEnglish (US)
Pages (from-to)770-773
Number of pages4
JournalArchives of ophthalmology
Volume113
Issue number6
DOIs
StatePublished - Jun 1995

    Fingerprint

ASJC Scopus subject areas

  • Ophthalmology

Cite this