Prevalence of congenital cardiovascular malformations in children of human immunodeficiency virus-infected women: The prospective P2C2 HIV multicenter study

Wyman W. Lai, Steven E Lipshultz, Kirk A. Easley, Thomas J. Starc, Stacey E. Drant, J. Timothy Bricker, Steven D. Colan, Douglas S. Moodie, George Sopko, Samuel Kaplan

Research output: Contribution to journalArticle

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Abstract

Objectives. The purpose of the study was to assess the effects of maternal HIV-1 (human immunodeficiency virus) infection and vertically transmitted HIV-1 infection on the prevalence of congenital cardiovascular malformations in children. Background. In the United States, an estimated 7000 children are born to HIV-infected women annually. Previous limited reports have suggested an increase in the prevalence of congenital cardiovascular malformations in vertically transmitted HIV-infected children. Methods. In a prospective longitudinal multicenter study, diagnostic echocardiograms were performed at 4-6-month intervals on two cohorts of children exposed to maternal HIV-1 infection: 1) a Neonatal Cohort of 90 HIV, infected, 449 HIV-uninfected and 19 HIV-indeterminate children; and 2) an Older HIV-Infected Cohort of 201 children with vertically transmitted HIV-1 infection recruited after 28 days of age. Results. In the Neonatal Cohort, 36 lesions were seen in 36 patients, yielding an overall congenital cardiovascular malformation prevalence of 6.5% (36/558), with a 8.9% (8/90) prevalence in HIV-infected children and a 5.6% (25/449) prevalence in HIV- uninfected children. Two children (2/558, 0.4%) had cyanotic lesions. In the Older HIV-Infected Cohort, there was a congenital cardiovascular malformation prevalence of 7.5% (15/201). The distribution of lesions did not differ significantly between the groups. Conclusions. There was no statistically significant difference in congenital cardiovascular malformation prevalence in HIV, infected versus HIV-uninfected children born to HIV-infected women. With the use of early screening echocardiography, rates of congenital cardiovascular malformations in both the HIV-infected and HIV-uninfected children were five, to ten-fold higher than rates reported in population- based epidemiologic studies but not higher than in normal populations similarly screened. Potentially important subclinical congenital cardiovascular malformations were detected.

Original languageEnglish
Pages (from-to)1749-1755
Number of pages7
JournalJournal of the American College of Cardiology
Volume32
Issue number6
DOIs
StatePublished - Nov 15 1998
Externally publishedYes

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Multicenter Studies
HIV
HIV-1
HIV Infections
Mothers
HIV-2
Virus Diseases
Population
Longitudinal Studies
Echocardiography
Epidemiologic Studies

ASJC Scopus subject areas

  • Nursing(all)

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Prevalence of congenital cardiovascular malformations in children of human immunodeficiency virus-infected women : The prospective P2C2 HIV multicenter study. / Lai, Wyman W.; Lipshultz, Steven E; Easley, Kirk A.; Starc, Thomas J.; Drant, Stacey E.; Timothy Bricker, J.; Colan, Steven D.; Moodie, Douglas S.; Sopko, George; Kaplan, Samuel.

In: Journal of the American College of Cardiology, Vol. 32, No. 6, 15.11.1998, p. 1749-1755.

Research output: Contribution to journalArticle

Lai, WW, Lipshultz, SE, Easley, KA, Starc, TJ, Drant, SE, Timothy Bricker, J, Colan, SD, Moodie, DS, Sopko, G & Kaplan, S 1998, 'Prevalence of congenital cardiovascular malformations in children of human immunodeficiency virus-infected women: The prospective P2C2 HIV multicenter study', Journal of the American College of Cardiology, vol. 32, no. 6, pp. 1749-1755. https://doi.org/10.1016/S0735-1097(98)00449-5
Lai, Wyman W. ; Lipshultz, Steven E ; Easley, Kirk A. ; Starc, Thomas J. ; Drant, Stacey E. ; Timothy Bricker, J. ; Colan, Steven D. ; Moodie, Douglas S. ; Sopko, George ; Kaplan, Samuel. / Prevalence of congenital cardiovascular malformations in children of human immunodeficiency virus-infected women : The prospective P2C2 HIV multicenter study. In: Journal of the American College of Cardiology. 1998 ; Vol. 32, No. 6. pp. 1749-1755.
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abstract = "Objectives. The purpose of the study was to assess the effects of maternal HIV-1 (human immunodeficiency virus) infection and vertically transmitted HIV-1 infection on the prevalence of congenital cardiovascular malformations in children. Background. In the United States, an estimated 7000 children are born to HIV-infected women annually. Previous limited reports have suggested an increase in the prevalence of congenital cardiovascular malformations in vertically transmitted HIV-infected children. Methods. In a prospective longitudinal multicenter study, diagnostic echocardiograms were performed at 4-6-month intervals on two cohorts of children exposed to maternal HIV-1 infection: 1) a Neonatal Cohort of 90 HIV, infected, 449 HIV-uninfected and 19 HIV-indeterminate children; and 2) an Older HIV-Infected Cohort of 201 children with vertically transmitted HIV-1 infection recruited after 28 days of age. Results. In the Neonatal Cohort, 36 lesions were seen in 36 patients, yielding an overall congenital cardiovascular malformation prevalence of 6.5{\%} (36/558), with a 8.9{\%} (8/90) prevalence in HIV-infected children and a 5.6{\%} (25/449) prevalence in HIV- uninfected children. Two children (2/558, 0.4{\%}) had cyanotic lesions. In the Older HIV-Infected Cohort, there was a congenital cardiovascular malformation prevalence of 7.5{\%} (15/201). The distribution of lesions did not differ significantly between the groups. Conclusions. There was no statistically significant difference in congenital cardiovascular malformation prevalence in HIV, infected versus HIV-uninfected children born to HIV-infected women. With the use of early screening echocardiography, rates of congenital cardiovascular malformations in both the HIV-infected and HIV-uninfected children were five, to ten-fold higher than rates reported in population- based epidemiologic studies but not higher than in normal populations similarly screened. Potentially important subclinical congenital cardiovascular malformations were detected.",
author = "Lai, {Wyman W.} and Lipshultz, {Steven E} and Easley, {Kirk A.} and Starc, {Thomas J.} and Drant, {Stacey E.} and {Timothy Bricker}, J. and Colan, {Steven D.} and Moodie, {Douglas S.} and George Sopko and Samuel Kaplan",
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T1 - Prevalence of congenital cardiovascular malformations in children of human immunodeficiency virus-infected women

T2 - The prospective P2C2 HIV multicenter study

AU - Lai, Wyman W.

AU - Lipshultz, Steven E

AU - Easley, Kirk A.

AU - Starc, Thomas J.

AU - Drant, Stacey E.

AU - Timothy Bricker, J.

AU - Colan, Steven D.

AU - Moodie, Douglas S.

AU - Sopko, George

AU - Kaplan, Samuel

PY - 1998/11/15

Y1 - 1998/11/15

N2 - Objectives. The purpose of the study was to assess the effects of maternal HIV-1 (human immunodeficiency virus) infection and vertically transmitted HIV-1 infection on the prevalence of congenital cardiovascular malformations in children. Background. In the United States, an estimated 7000 children are born to HIV-infected women annually. Previous limited reports have suggested an increase in the prevalence of congenital cardiovascular malformations in vertically transmitted HIV-infected children. Methods. In a prospective longitudinal multicenter study, diagnostic echocardiograms were performed at 4-6-month intervals on two cohorts of children exposed to maternal HIV-1 infection: 1) a Neonatal Cohort of 90 HIV, infected, 449 HIV-uninfected and 19 HIV-indeterminate children; and 2) an Older HIV-Infected Cohort of 201 children with vertically transmitted HIV-1 infection recruited after 28 days of age. Results. In the Neonatal Cohort, 36 lesions were seen in 36 patients, yielding an overall congenital cardiovascular malformation prevalence of 6.5% (36/558), with a 8.9% (8/90) prevalence in HIV-infected children and a 5.6% (25/449) prevalence in HIV- uninfected children. Two children (2/558, 0.4%) had cyanotic lesions. In the Older HIV-Infected Cohort, there was a congenital cardiovascular malformation prevalence of 7.5% (15/201). The distribution of lesions did not differ significantly between the groups. Conclusions. There was no statistically significant difference in congenital cardiovascular malformation prevalence in HIV, infected versus HIV-uninfected children born to HIV-infected women. With the use of early screening echocardiography, rates of congenital cardiovascular malformations in both the HIV-infected and HIV-uninfected children were five, to ten-fold higher than rates reported in population- based epidemiologic studies but not higher than in normal populations similarly screened. Potentially important subclinical congenital cardiovascular malformations were detected.

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