Prevalence of antiretroviral drug resistance and resistance-associated mutations in antiretroviral therapy-naïve HIV-infected individuals from 40 United States cities

Lisa Ross, Michael L. Lim, Qiming Liao, Brian Wine, Allan E Rodriguez, Winkler Weinberg, Mark Shaefer

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Background: Transmission of drug-resistant HIV strains to antiretroviral therapy (ART)-naïve subjects can negatively impact therapy response. As treatment strategies and utilization of antiretroviral drugs evolve, patterns of transmitted mutations may shift. Method: Paired genotypic and phenotypic susceptibility data were retrospectively analyzed for 317 ART-naïve, HIV-1-infected subjects from 40 small and major metropolitan cities in the Northeastern, Midwestern, Southern, Southwestern, and Northwestern United States during 2003. Results: Using current (January 2007) PhenoSense cutoffs, HIV-1 from 8% of subjects had reduced susceptibility to >1 drug. By class, <1% had reduced susceptibility to protease inhibitors (PIs), and 1 % had reduced susceptibility to nucleoside reverse transcriptase inhibitors (NRTIs); reduced susceptibility to >1 non-nucleoside reverse transcriptase inhibitor (NNRTIs) was seen in 7% of subjects, with 4% of all subjects having reduced susceptibility to all NNRTIs. IAS-USA-defined NRTI, NNRTI, and/or major PI HIV-1 drug resistance-associated mutations were detected for 10% of the subjects. HIV risk factors included homosexual contact (74%), heterosexual contact (28%), and injectable drug use/transfusion/other (7%). Reduced susceptibility to >1 drug was significantly higher (p = .034) for white subjects than African Americans and Hispanics/others. Conclusion: The high prevalence of drug resistance in these ART-naïve subjects suggests that transmitted resistance is occurring widely within the United States. HIV genotyping and/or phenotyping for antiretroviral-naïve patients seeking treatment should be considered, especially if the therapy will include an NNRTI.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalHIV Clinical Trials
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2007

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Keywords

  • Antiretroviral naïve
  • HIV
  • Prevalence
  • Reduced susceptibility
  • Resistance
  • Transmission

ASJC Scopus subject areas

  • Virology
  • Immunology

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