Prevalence of antibodies to 3 retroviruses in a captive colony of macaque monkeys

M. D. Daniel, N. L. Letvin, P. K. Seghal, D. K. Schmidt, D. P. Silva, K. R. Solomon, F. S. Hodi, D. J. Ringler, R. D. Hunt, N. W. King, Ronald Charles Desrosiers

Research output: Contribution to journalArticle

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Abstract

The prevalence of antibodies to 3 retroviruses in the macaque colony of the New England Regional Primate Research Center (NERPRC) was determined using enzyme-linked immunosorbent assay procedures as well as radioimmunoprecipitation-SDS polyacrylamide gel electrophoresis and indirect immunofluorescence tests. Out of 848 macaques, 3 (0.35%) had antibodies to simian immunodeficiency virus (SIV), 27 (3.2%) had antibodies to simian T-lymphotropic virus type I (STLV-I) and approximately 285 (34%) had antibodies to type D retrovirus. Of 3 macaques infected with SIV, 2 were rhesus monkeys (Macaca mulatta) and 1 was a cynomolgus monkey (Macaca fascicularis). STLV-I and D retrovirus infection occurred in all 4 macaque species examined. SIV, STLV-I and D retroviruses were isolated from sero-positive macaques. The low prevalence of SIV infection suggests that SIV is not being readily transmitted among macaques at NERPRC; this contrasts markedly with the high SIV prevalence in some captive mangabey colonies. In contrast to African green monkeys from eastern Africa, 160 Carribean green monkeys examined showed no sign of SIV infection. These results provide a framework for monitoring spontaneous disease associated with infection by these 3 retroviruses and will help in further definition of STLV-I and SIV infection of non-human primates as animal models for human disease.

Original languageEnglish (US)
Pages (from-to)601-608
Number of pages8
JournalInternational Journal of Cancer
Volume41
Issue number4
StatePublished - 1988
Externally publishedYes

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Simian Immunodeficiency Virus
Macaca
Retroviridae
Haplorhini
Simian T-lymphotropic virus 1
Antibodies
Virus Diseases
Retroviridae Infections
Primates
Cercopithecus aethiops
New England
Macaca fascicularis
Macaca mulatta
Cercocebus
Betaretrovirus
Wiskott-Aldrich Syndrome
Animal Disease Models
Eastern Africa
Indirect Fluorescent Antibody Technique
Research

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Daniel, M. D., Letvin, N. L., Seghal, P. K., Schmidt, D. K., Silva, D. P., Solomon, K. R., ... Desrosiers, R. C. (1988). Prevalence of antibodies to 3 retroviruses in a captive colony of macaque monkeys. International Journal of Cancer, 41(4), 601-608.

Prevalence of antibodies to 3 retroviruses in a captive colony of macaque monkeys. / Daniel, M. D.; Letvin, N. L.; Seghal, P. K.; Schmidt, D. K.; Silva, D. P.; Solomon, K. R.; Hodi, F. S.; Ringler, D. J.; Hunt, R. D.; King, N. W.; Desrosiers, Ronald Charles.

In: International Journal of Cancer, Vol. 41, No. 4, 1988, p. 601-608.

Research output: Contribution to journalArticle

Daniel, MD, Letvin, NL, Seghal, PK, Schmidt, DK, Silva, DP, Solomon, KR, Hodi, FS, Ringler, DJ, Hunt, RD, King, NW & Desrosiers, RC 1988, 'Prevalence of antibodies to 3 retroviruses in a captive colony of macaque monkeys', International Journal of Cancer, vol. 41, no. 4, pp. 601-608.
Daniel MD, Letvin NL, Seghal PK, Schmidt DK, Silva DP, Solomon KR et al. Prevalence of antibodies to 3 retroviruses in a captive colony of macaque monkeys. International Journal of Cancer. 1988;41(4):601-608.
Daniel, M. D. ; Letvin, N. L. ; Seghal, P. K. ; Schmidt, D. K. ; Silva, D. P. ; Solomon, K. R. ; Hodi, F. S. ; Ringler, D. J. ; Hunt, R. D. ; King, N. W. ; Desrosiers, Ronald Charles. / Prevalence of antibodies to 3 retroviruses in a captive colony of macaque monkeys. In: International Journal of Cancer. 1988 ; Vol. 41, No. 4. pp. 601-608.
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