Prevalence, associated factors, and comorbid conditions for ménière's disease

Jessica S. Tyrrell, David J.D. Whinney, Obioha C. Ukoumunne, Lora E. Fleming, Nicholas J. Osborne

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

OBJECTIVES: The aims of this study were to estimate the prevalence of Ménière's disease and investigate its relationship with: demographic factors; symptoms and conditions that are known or hypothesized to be associated with Ménière's disease; other physical diseases; mental health. DESIGN: The authors used cross-sectional data from the UK Biobank to compare 1376 self-reported Ménière's participants with over 500,000 without Ménière's. The data set has comprehensive anthropometric measures, questionnaire data investigating health, well-being, diet, and medical and drug-prescribing history for each participant. The authors used logistic regression models to investigate the relationship of Ménière's disease with: demographic factors; symptoms and conditions that are known or hypothesized to be associated with Ménière's disease; other physical diseases; and mental health. RESULTS: Ménière's disease was more common in participants who were older (adjusted odds ratio per 10-year increase: 1.5 [95% confidence interval:1.4-1.6]), white (odds ratio: 1.7;1.2-2.3), female (1.4;1.3-1.6), and having higher body mass index categories (p < 0.001). The Ménière's group had greater odds of hearing difficulty (10.9;9.6-12.5), current tinnitus (68.3;47.8-97.5), and had fallen more than once in the last year (2.1;1.8-2.5). Ménière's participants had greater odds of reporting at least one disease from each grouping of allergic, immune dysfunction, or autonomic dysfunction (2.2;1.8-2.6), and poor mental health (2.1;1.8-2.5). CONCLUSIONS: This study provides an evidence base that improves understanding of Ménière's disease. Associations were noted with a number of diseases, and the authors hypothesize a role for the autonomic nervous system and immune system dysfunction in Méniè re's etiology. The study also highlights the physical and mental health correlates of the condition.

Original languageEnglish (US)
Pages (from-to)e162-e169
JournalEar and hearing
Volume35
Issue number4
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Autoimmune
  • Autonomic nervous system
  • Epidemiology
  • Ménière's disease
  • UK Biobank

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Speech and Hearing

Cite this

Tyrrell, J. S., Whinney, D. J. D., Ukoumunne, O. C., Fleming, L. E., & Osborne, N. J. (2014). Prevalence, associated factors, and comorbid conditions for ménière's disease. Ear and hearing, 35(4), e162-e169. https://doi.org/10.1097/AUD.0000000000000041